老年脑卒中后抑郁危险因素的Meta分析

目的 系统评价老年脑卒中后抑郁（post-stroke depression，PSD）的危险因素。方法 检索中英文数据库，搜集建库至2021年4月有关老年人PSD危险因素的病例对照研究，完成文献筛选及质量评价后采用RevMan 5.4软件进行Meta分析。结果 共纳入文献20篇，研究对象7 553例，涉及危险因素14个。分析结果显示:性别（ OR =1.32，95% CI :1.19～1.45， P ＜0.01）、糖尿病（ OR =1.18，95% CI :1.01～1.39， P= 0.04）、冠心病（ OR =1.41，95% CI :1.14～1.76， P ＜0.01）、日常生活能力（ MD =-20.73，95% CI :-28.34～-13.12， P ＜0.01）、婚姻状况（ OR =2.09，95% CI :1.61～2.70， P ＜0.01）和家庭氛围（ OR =2.82，95% CI :2.22～3.59， P ＜0.01）为老年人PSD的危险因素。结论 性别、糖尿病、冠心病、日常生活能力（activities of daily living，ADL）、婚姻状况、家庭氛围为老年人PSD的危险因素。

Meta-analysis of risk factors for post-stroke depression in elderly patients

Objective To systematically evaluate the risk factors of post-stroke depression in the elderly.]Methods A case-control study on the risk factors of post-stroke depression in the elderly from the establishment of the database to April 2021 was collected. After literature screening and quality evaluation, Meta analysis was conducted by RevMan5.4 software.]Results A total of 20 articles were included and 7553 subjects were studied. There were 14 risk factors involved. The results showed that: gender (OR=1.32,95%CI=1.19-1.45,P<0.01), diabetes(OR=1.18,95%CI=1.01-1.39,P=0.04),coronary heart disease (OR=1.41,95%CI=1.14-1.76,P<0.01), activities of daily living (MD=-20.73,95%CI=-28.34--13.12,P<0.01), marital status (OR=2.09,95%CI=1.61-2.70,P<0.01) and family atmosphere (OR=2.82,95%CI=2.22-3.59,P<0.01)were the risk factors for post-stroke depression in the elderly.]Conclusion Gender, diabetes, coronary heart disease, activities of daily living (ADL), marital status, and family atmosphere are the risk factors of post-stroke depression in the elderly.