老年认知衰弱的危险因素Meta分析

目的 通过Meta分析明确老年人发生认知衰弱的危险因素。 方法 计算机检索中英文数据库,检索时间从建库至2021年8月,使用RevMan 5.3软件进行Meta分析。结果 共纳入24篇文献,总样本量18 839例。Meta分析结果显示高龄(OR=2.65; 95%CI:2.19～3.20)、女性(OR=2.56; 95%CI:1.47～4.47)、文化程度较低(OR=2.13; 95%CI:1.32～3.43)、较少运动(OR=3.60; 95%CI:2.47～5.23)、久坐行为(OR=2.26; 95%CI:1.62～3.17)、无智力活动(OR=3.00; 95%CI:1.69～5.33)、抑郁(OR=3.51; 95%CI:2.92～4.21)、睡眠不足(OR=2.30; 95%CI:1.74～3.03)、多病共存(OR=3.03; 95%CI:1.97～4.66)、糖尿病史(OR=2.65; 95%CI:2.10～3.36)、HbA1c≥8.5%(OR=3.24; 95%CI:1.65～6.39)、营养不良(OR=3.06; 95%CI:2.19～4.30)和跌倒史(OR=4.03; 95%CI:2.52～6.43)是老年认知衰弱的危险因素。 结论 老年认知衰弱的发生受多种因素影响,应重点关注高危人群,尽早采取干预措施,以降低认知衰弱的发生率。

Meta-analysis of risk factors of cognitive frailty in the elderly

Objective To clarify the risk factors of cognitive frailty in the elderly through meta-analysis. Methods Chinese and English databases were searched by computer from database constructed until August 2021. Meta-analysis was performed using RevMan 5.3 software. Results A total of 24 essays were included, with a total sample size of 18 839 cases. Meta-analysis showed that older age(OR=2.65; 95%CI: 2.19-3.20), female(OR=2.56; 95%CI: 1.47-4.47), lower educational level(OR=2.13; 95%CI: 1.32-3.43), less exercise(OR=3.60; 95%CI: 2.47-5.23), sedentary behavior(OR=2.26; 95%CI: 1.62-3.17), no intellectual activity(OR=3.00; 95%CI: 1.69-5.33), depression(OR=3.51; 95%CI: 2.92-4.21), sleep insufficiency(OR=2.30; 95%CI: 1.74-3.03), co-morbid chronic diseases(OR=3.03; 95%CI: 1.97-4.66), diabetic history(OR=2.65; 95%CI: 2.10-3.36), HbA1c≥8.5%(OR=3.24; 95%CI: 1.65-6.39), malnutrition(OR=3.06; 95%CI: 2.19-4.30)and fall history(OR=4.03; 95%CI: 2.52-6.43)were risk factors for cognitive frailty in the elderly. Conclusion The occurrence of cognitive frailty in the elderly is affected by many factors. We should focus on high-risk groups and take intervention measures to reduce the incidence of cognitive frailty.