Serum IL-6 level as a marker of disease activity in ankylosing spondylitis patients with pure axial involvement |
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| Affiliation: | 1. Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico;2. Doctorado en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico;3. Doctorado en Genética Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico;4. Hospital de Especialidades del Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico;1. Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, 62209 Cuernavaca, Morelos, Mexico;2. Laboratorio de Química Orgánica, Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43, No. 130, Colonia Chuburná de Hidalgo, Mérida, Yucatán, Mexico;3. Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Mexico 54090, Mexico;1. Rheumatology Department Charles Nicolle Hospital, 1006 Bab Souika, El Manar Tunis University, Tunisia;2. Rheumatology Department Kassab Institute, 2010 Ksar Said, El Manar Tunis University, Research Unit UR17SP04, Tunisia;3. Rheumatology Department Farhat Hached Hospital, 4002 Sousse Medina, Sousse University, Tunisia;4. Rheumatology Department La Marsa Hospital, 2046 Sidi Daoued, El Manar Tunis University, Tunisia;5. Departments of Internal Medicine, Military Hospital, Tunisia;6. Epidemiology Department, El Manar Tunis University, Tunisia;7. Epidemiology Department, Monastir University, Tunisia;1. Ipswich Hospital NHS Trust, Ipswich, UK;2. Norwich Medical School, University of East Anglia, Norwich, UK |
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| Abstract: | BackgroundThe assessment of disease activity in patients with ankylosing spondylitis (AS) continues to be a challenging issue. The currently available markers like C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) show poor correlation with clinical disease activity.ObjectivesTo compare serum IL-6 and hs-CRP levels between patients with AS with pure axial involvement and healthy controls; and to correlate them with Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI) and Bath ankylosing spondylitis metrology index (BASMI).MethodsSixty-two consecutive patients of AS with pure axial involvement satisfying the modified New York criteria and 60 age-matched healthy controls were recruited. In all patients, Bath indices were measured and fasting venous blood samples for serum IL-6 and hs-CRP levels were obtained. Comparison of median of serum IL-6 and hs-CRP levels was done between cases and healthy controls and levels also correlated with Bath indices by appropriate statistical methods.ResultsThe median serum IL-6 and hs-CRP levels were significantly higher in cases as compared to healthy controls (p = 0.001). Serum IL-6 levels correlated significantly with BASDAI and BASFI (r = 0.61, p = 0.001 and r = 0.27, p = 0.032 respectively) but no correlation was found with BASMI (r = −0.08, p = 0.53). Serum hs-CRP did not correlate with Bath indices except BASMI (r = 0.28, p = 0.03).ConclusionSerum IL-6 levels can be reliably used as an aid in monitoring of disease activity in AS patients with pure axial involvement. |
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| Keywords: | Axial ankylosing spondylosis Marker of disease activity Serum IL-6 |
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