Characterization of ocular pharmacokinetics of tilisolol after instillation into anesthetized rabbits |
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Authors: | Sasaki H Yamamura K Mukai T Nishida K Nakamura J Nakashima M Ichikawa M |
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Institution: | Department of Hospital Pharmacy, Nagasaki University School of Medicine, Japan. |
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Abstract: | The purpose of this study was to characterize the ocular pharmacokinetics of a beta-blocker, tilisolol, after instillation into anesthetized rabbits using a mathematical model including a diffusion process. The samples were analyzed by HPLC. Anesthetized rabbit was used as a model of tear secretion deficiency. Anesthetized rabbits showed higher drug concentration in the tear fluid and aqueous humor after instillation than unanesthetized rabbits. A mathematical model including a diffusion process and in vivo penetration parameters well described the concentrations of tilisolol in the aqueous humor after instillation in anesthetized rabbits. |
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