乳腺癌组织中错配修复基因MSH2和细胞周期蛋白D1表达的相关性及其意义

目的探讨乳腺浸润性导管癌中错配修复基因MSH2蛋白的表达与细胞周期蛋白D1（cyclinD1）表达的关系及意义。方法制作组织芯片用免疫组织化学方法检测67例乳腺浸润性导管癌标本中MSH2和CyclinD1蛋白的表达。结果67例乳腺浸润性导管癌组织中，MSH2蛋白的阳性表达率为53．7％（36／67），CyclinD11蛋白的阳性表达率为47．8％（32／67）。MSH2和CyclinD1蛋白表达均与淋巴结转移状态相关（P〈0．05）。MSH2和CyclinD1表达呈负相关（r=-0．251，P=0．040）。结论CyclinD1可能通过下调MSH2蛋白水平，影响DNA错配修复系统而促进乳腺癌的发生和发展。

Relationship between expression of MutS homolog2 and CyclinD1 proteins in breast cancer tissues and its significance

Objective To explore the relationship between the expression of MutS homolog2 （MSH2） and CyclinD1 proteins in breast cancer and their clinical significance. Methods Expression of MSH2 and CyclinD1 proteins was detected in 67 cases of invasive ductal carcinoma of the breast by immunohistochemistry. Results The positive expression rate of MSH2 and CyclinD1 proteins was 53.7% （ 36/67 ） and 47.8% （ 32/67 ） respectively. The expression of MSH2 and CyclinD1 protein was closely related to lymph nodes metastasis（ P 〈 0.05 ）. Expression of MSH2 and CyclinD1 protein was negatively correlated with each other in breast cancer（ r = -0. 251, P = 0. 040）. Conclusion CyclinD1 may play a role in DNA mismatch repair（MMR） system by downregulating the expression of MSH2 and thus influences the tumorigenesis and progression of breast cancer.