Genotoxicity of N-nitrosothiazolidine in microbial and hepatocellular test systems |
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Authors: | DJ Loury JL Byard T Shibamoto |
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Institution: | Department of Environmental Toxicology, University of California, Davis, CA 95616, USA |
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Abstract: | The genotoxicity of N-nitrosothiazolidine was studied in a microbial system and in a hepatocellular system. The compound showed positive responses in both tests, exhibiting weak mutagenicity at the lowest level tested (1 mg/plate) in the rec assay in Bacillus subtilis, and inducing statistically significant levels of DNA repair in primary hepatocyte cultures at concentrations ranging from 2 × 10?4 to . |
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