Presence of T-cell subset abnormalities in newly diagnosed cases of multiple sclerosis and relationship with short-term clinical activity |
| |
Authors: | M. Eoli M. Ferrarini A. Dufour S. Heltaj L. Bevilacqua G. Comi V. Cosi G. Filippini V. Martinelli C. Milanese L. LaMantia A. Salmaggi |
| |
Affiliation: | (1) Istituto Nazionale Neurologico C. Besta, Milan, Italy;(2) Istituto Scientifico S. Raffaele, Milan, Italy;(3) Ospedale Ca' Granda, Milan, Italy;(4) Istituto Scientifico Mondino, Pavia, Italy;(5) Istituto Neurologico C. Besta , Via Celoria, 11, I-20133 Milan, Italy |
| |
Abstract: | Abnormalities of T-cell subsets in patients with multiple sclerosis are well known; in order to assess whether immunological abnormalities are relevant in the pathogenesis of the disease after its clinical onset, peripheral blood lymphocyte subsets (CD3+, CD4+, CD4+ CD45RA+, CD4+CD45RA–, CD8+, CD8+CD57+, CD57+, CD25+) were analysed serially in 25 patients at the first clinical episode suggestive of inflammatory demyelinating disease and in an equal number of age- and sex-matched controls. During the follow-up period (12–18 months, mean 14) 6 of 25 patients presented new relapses: in this subgroup of patients, significant changes in CD4+ ratio (% CD4+CD45RA–/%CD4+CD45RA–) were detected in comparison both with healthy controls and with clinically stable patients. Patients clinically stable at follow-up did not display immunological abnormalities, regardless of the presence or absence of cerebrospinal fluid and/or magnetic resonance imaging alterations consistent with multiple sclerosis. These findings suggest a possible prognostic role of early T-cell subset imbalance in multiple sclerosis. |
| |
Keywords: | Multiple sclerosis T-cell subsets |
本文献已被 SpringerLink 等数据库收录! |
|