Strain and species differences in the induction of ATPase-deficient hepatic foci by diethylnitrosamine |
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| Authors: | R J Laib B Brockes A Schwaier H M Bolt |
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| Affiliation: | 1. Abteilung für Toxikologie, Pharmakologisches Institut, Universität Mainz, Obere Zahlbacher Strasse 67, D-6500 Mainz 1 F.R.G.;2. Battelle-Institut e. V., Am Römerhof 35, D-6000 Frankfurt/Main 90 F.R.G. |
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| Abstract: | Diethylnitrosamine (5 mg/kg) was intraperitoneally administered to rats, mice, guinea pigs and tupaias daily for 3 weeks. After 12 weeks of cessation, focal areas of ATPase-deficiency of hepatocytes appeared only in rats and, to a much lesser extent, in guinea pigs. Female rats were more sensitive than males and Wistar rats were less sensitive than Sprague-Dawley rats. These data show that quantitation of ATPase-deficient foci as a determinant of hepatocarcinogenicity is mainly restricted to the rat species. |
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| Keywords: | To whom correspondence should be addressed. |
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