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| 鄂贝缩醛A的结构解析与合成 | |
| 引用本文： | 吴继洲,阮汉利,姚念环,孙汉董,森实千香子,饭田彰,藤多哲朗.鄂贝缩醛A的结构解析与合成[J].药学学报,1999,34(8):600-604. |
| 作者姓名： | 吴继洲 阮汉利 姚念环 孙汉董 森实千香子 饭田彰 藤多哲朗 |
| 作者单位： | 1. 同济医科大学药学院,武汉 430030 2. 中国科学院昆明植物研究所,昆明 650204 3. 京都大学药学部,京都606-01,日本 4. 摄南大学药学部,大阪573-01,日本 |
| 摘 要： | 目的：研究民间药鄂北贝母Fritillaria ebeiensis G.D.Yu et G.Q.Ji鳞茎的非生物碱成分。方法：用MeOH提取，反复硅胶柱色谱分离与纯化，经理化常数测定、波谱解析、化学合成及降解反应，确定其结构。结果：从乙酸乙酯萃取物中分离鉴定了1个二萜，其结构为ent-kauran-16β,17-acetal ent-16β-kauran-17(S)-aldehyde (1)。结论：化合物1为新的对映-贝壳杉烷型缩醛聚合二萜,命名为鄂贝缩醛A(fritillebinide A)。 |
| 关 键 词： | 贝母属 鄂北贝母 鄂贝缩醛A 对映-贝壳杉烷二萜 聚合缩醛 |
| 修稿时间： | : 1998-12- |
STRUCTURAL ELUCIDATION AND SYNTHESIS OF FRITILLEBINIDE A FROM BULBS OF FRITILLARIA EBEIENSIS |
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| Wu Jizhou,Ruan Hanli,Yao Nianhuan,Sun Handong,Morizane C,Iida A,Fujitd T.STRUCTURAL ELUCIDATION AND SYNTHESIS OF FRITILLEBINIDE A FROM BULBS OF FRITILLARIA EBEIENSIS[J].Acta Pharmaceutica Sinica,1999,34(8):600-604. | |
| Authors: | Wu Jizhou Ruan Hanli Yao Nianhuan Sun Handong Morizane C Iida A Fujitd T |
| Abstract: | AIM: To sutdy the non-basic constituents of the Chinese herbal drug “Ebeibeimu”, the bulus of Fritillaria ebeiensis G.D.Yu et G.Q.Ji, in order to appraise its quality systematically. METHODS: MeOH extraction and silica gel column chromatography were to isolate pure compound, its structure was determined with various spectral analysis including 2D-NMR techniques and chemical methods. RESULTS: A diterpenoid has been isolated from the EtOAc fraction of the bulus of Fritillaria ebeiensis, growing in the Suizhou disrtict of Hubei province, China. It was established as ent-kauran-16β,17-acetal ent-16β-kauran-17(S)-aldehyde (1) on the basis of physicochemical and spectral data and chemical synthesis. CONCLUSION: Compound 1 is a novel acetal diterpenoid dimer with ent-kaurane skeleton, named fritillebinide A. |
| Keywords: | Fritillaria Fritillaria ebeiensis fritillebinide A ent kaurane diterpenoid dimer |
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