肺癌患者咽部、血液、癌组织EB病毒感染及其关系初探

目的:探讨肺癌患者咽部分泌物、血液及癌组织中EB病毒感染情况与肺癌的关系.方法:应用PCR技术和ELISA法对采自30例进展期肺癌患者的咽部分泌物、血液及新鲜肺癌组织标本进行EB病毒检测.结果:肺癌患者咽部分泌物EB病毒感染率低,差异无显著性(P＞0.05);血液EB病毒VCA-IgG抗体高于非癌胸疾病患者(P＜0.01);癌组织中EB病毒感染率为43.3%;不同病理类型肺癌EB病毒感染率差异无显著性;肺癌患者癌组织EB病毒感染率与血液EB病毒VCA-IgG抗体之间呈中度相关.结论:肺癌患者血液及癌组织中EB病毒感染存在增高现象,EB病毒长期感染与肺癌关系密切.

The Observation of EBV Infection at Pharyngeal Section, Blood and Tumor Tissue of Lung Cancer Patients and the Relation between Them

Objective: To investigate the relation between the lung cancer and the EBV in pharyngeal secretion, blood and tumor tissue of lung cancer patients. Methods: PCR and ELISA methods was used to detect EBV in pharygeal secretion, fresh lung cancer tissue and blood specimen taken from 30 patients with lung cancer in progressing period. Results: EBV infection rate of pharyngeal secretion was low, and there was no difference between the patients with lung cancer and with non-tumorous chest disease. EBV VCA-IgG antibody of lung cancer patients was superior to that of non-tumorous chest disease patients. EBV infection rate of lung cancer tissue was 43.3%, and there was no difference among various kinds of pathogen with EBV infection. There was a medium correlation between EBV infection in lung cancer tissue and blood EBV VCA-IgG antibody. Conclusions: EBV in lung cancer patients, blood and tumor tissue have been increasing. There is a close relation between lung cancer and long-term EBV infection.