活动期溃疡性结肠炎临床疗效评价

目的:分析溃疡性结肠炎(UC)活动期的临床疗效及治疗转归,评价预后相关因素。方法:回顾性分析我院128例住院患者的病例资料,记录临床表现及诊疗经过,对柳氮磺吡啶(SASP)或5-氨基水杨酸(5-ASA),糖皮质激素,免疫抑制剂,灌肠,外科手术等治疗方法的疗效进行评价。结果:活动期UC患者中,轻度占25.0%(32/128),中度占53.9%(69/128),重度占21.1%(27/128);SASP或5-ASA是控制症状的主要药物,对于中度UC患者,联合用药治疗效果较为理想。而发病年龄轻、结肠病变范围大、低血红蛋白、大便以血为主、低血清白蛋白、病变伴有溃疡是提示疗效差的相关因素。结论:对于UC病变处于活动期时,应及时评估病情严重程度,选择疗效相对较好的治疗方案,并分析影响疗效相关因素。

Evaluation of the clinical curative effects on active ulcerative colitis

Objective:To evaluate the curative effect and transformation of active ulcerative colitis,and to find out the relating factors indicating its curative effect and prognosis.Methods:A retrospective study was performed on the clinical features,diagnosis and treatments of 128 inpatients in our hospital,and the curative effects of SASP/5-ASA,glucocorticoid,clysis,immunosuppressor as well as surgical operation were evaluated.Results:Among all the active ulcerative colitis patients,25.0%(32/128) were with mild changes,53.9%(69/128) were moderate,and the rest 21.1%(27/128) were severe.SASP/5-ASA were the chief symptom-controlling agents,and the combination of two was be more effective for especially the moderate ulcerative colitis.Early onsetage,large area of colon changes,low hematoglobin,bloody stool,low serum albumin and ulcerative changes were shown to be the indications of poor curative effects.Conclusion:A timely assessment,choice of appropriate therapies,and analysis on effect-relating factors were extremely important to the management of active ulcerative colitis.