急性Dieldrin中毒对C57BL小鼠纹状体多巴胺含量的影响

目的：探讨急性Ｄｉｅｌｄｒｉｎ（氧桥氯甲桥奈）中毒对Ｃ５７ＢＬ 小鼠纹状体多巴胺及其代谢产物含量的影响。方法：给３组小鼠分别喂食 Ｄｉｅｌｄｒｉｎ ５０ ｍｇ·ｋｇ－１体重、Ｄｉｅｌｄｒｉｎ ４０ ｍｇ·ｋｇ－１体重和等量的生理盐水，３ ｈ后处死小鼠，取纹状体匀浆用高效液相色谱－电化学检测法测定纹状体中多巴胺（ＤＡ）、５－羟色胺（５－ＨＴ）、高香草酸（ＨＶＡ）、５－羟基吲哚乙酸（５－ＨＩＡＡ）和去甲肾上腺素（ＮＡ）的含量。结果：喂食 Ｄｉｅｌｄｒｉｎ ５０ ｍｇ·ｋｇ－１体重能降低小鼠纹状体中 ＮＡ、ＤＡ及 ＨＶＡ的含量．结论：大剂量的Ｄｉｅｌｄｒｉｎ可影响小鼠纹状体中 ＤＡ的代谢．可能是致帕金森病的环境因素之一。

The Influence of Acute Intoxication of Dieldrin on the Level of Dopamine in Striatum of Mice

Aim: To study the effect of Dieldrin on dopamine (DA),serotonin (5-HT)and their metabolites. Methods; The C57- BL mice were divided into 3 groups,and were administrated orally Dieldrin 50mg/kg body weight,40mg/kg body weight and equal amount normal saline,respectively. 3 hours later,these mice were decapitated,and the striatums were isolated from the brains. The levels of dopamine (DA ), serotonin (5-HT), homovanillic acid (HVA ), 5-hydroxyindoleacetic acid (5-'HIAA ) and norepinephrine (NA)in the striatum were measured by high-performance liquid chromatography with electrochemical detection (HLPC-EC ). Results :Dieldrin (50 mg/kg body weight)can decrease the concentrations of DA and NA in the striatum of mice. Conclusion:Dieldrin at great dose can influence metabolism of DA in the striatum of mice and it may be one of the environ- mental factors inducing Parkinson's disease (PD).