| 迷走神经刺激对癫癎大鼠间脑部分核团c-fos蛋白表达的影响 |
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| 引用本文： | 唐敏峰,丁炯,张璐,李雷,韩群颖,TANG Min-feng,DING Jiong,ZHANG Lu,LI Lei,HAN Qun-ying. 迷走神经刺激对癫癎大鼠间脑部分核团c-fos蛋白表达的影响[J]. 南京医科大学学报(自然科学版), 2005, 25(9): 624-626,F0002 |
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| 作者姓名： | 唐敏峰 丁炯 张璐 李雷 韩群颖 TANG Min-feng DING Jiong ZHANG Lu LI Lei HAN Qun-ying |
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| 作者单位： | 南京医科大学人体解剖学系,江苏南京210029 |
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| 基金项目： | 江苏省分子神经生物重点实验室开放科研基金资助项目（KJS03055）;南京医科大学科技发展基金资助项目（NY200008） |
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| 摘 要： | 目的：研究丘脑室旁核（PV）、下丘脑室旁核（PVN）在迷走神经刺激（VNS）抑制癫痫发作的过程中c-fos蛋白表达的变化。方法：利用海人藻酸（KA）诱发大鼠癫痫，结合c-fos免疫组化，分对照组、VNS组、KA组、VNS＋KA组观察PV、PVN内c-fos阳性细胞的数日变化。结果：VNS组PV、PVN内c-fos阳性细胞数高于对照组：VNS4-KA组PV、PVN内c-fos阳性细胞数低于KA组。结论：PV、PVN可能参与了VNS抑制癫痫过程。
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| 关 键 词： | 迷走神经刺激 室旁核 下丘脑室旁核 癫痫 |
| 文章编号： | 1007-4368（2005）09-0624-03 |
| 收稿时间： | 2005-01-20 |
| 修稿时间： | 2005-01-20 |
Expression of fos like protein in diencephalon after vagus nerve stimulation in epileptic rats |
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| Tang MinFeng;Ding Jiong;Zhang Lu;Li Lei;Han QunYing. Expression of fos like protein in diencephalon after vagus nerve stimulation in epileptic rats[J]. Acta Universitatis Medicinalis Nanjing, 2005, 25(9): 624-626,F0002 |
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| Authors: | Tang MinFeng Ding Jiong Zhang Lu Li Lei Han QunYing |
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| Abstract: | Objective: To investigate the quantitative changes of fos like positive neurons in paraventricular nucleus of thalamus(PV) and paraventricular nucleus of hypothalamus (PVN) involved in the inhibition of vagus nerve stimulation (VNS) on epilepsy.Methods: Using the kainic acid (KA) kinding epilepsy rats, we observed the quantitative changes of fos like positive neurons in PVand PVN after VNS treatment combined with immunohistochemical method. Results: VNS induced a significant increase inimmunoreactivity in PV and PVN compared with the control group; VNS induced a significant decrease in PV and PVN in VNS KAgroup compared with KA group. Conclusion: PV and PVN could be involved in anti-epilepsy. |
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| Keywords: | vagus nerve stimulation paraventricular nucleus of thalamus paraventricular nucleus of hypothalamus epilepsy |
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