| 维甲酸对体外培养成纤维细胞DNA合成的影响 |
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| 引用本文： | 宋维铭,管正玉,孙广慈,徐炎. 维甲酸对体外培养成纤维细胞DNA合成的影响[J]. 中华烧伤杂志, 1995, 0(2) |
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| 作者姓名： | 宋维铭 管正玉 孙广慈 徐炎 |
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| 作者单位： | 中国医学科学院整形外科医院，中国医学科学院整形外科医院，中国医学科学院整形外科医院，中国医学科学院基础医学研究所 北京100041，北京100041，北京100041 |
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| 摘 要： | 观察了维甲酸对体外培养成纤维细胞DNA合成的影响,结果证明维甲酸对其合成有不同程度的抑制作用,呈剂量效应关系,并探讨了维甲酸治疗瘢痕的可能作用机理。
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| 关 键 词： | 瘢痕 成纤维细胞 维甲酸 细胞培养 ~3H-TdR参入 |
The effect of retinoic acid on DNA synthesis of fibroblast.in vitro culture |
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| Song Weiming Guan Zhengyu Sun Guangci,The Plastic Surgery Hospital of Chinese Academy of Medical Sciences,Beijing. The effect of retinoic acid on DNA synthesis of fibroblast.in vitro culture[J]. Chinese journal of burns, 1995, 0(2) |
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| Authors: | Song Weiming Guan Zhengyu Sun Guangci The Plastic Surgery Hospital of Chinese Academy of Medical Sciences Beijing |
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| Affiliation: | Song Weiming Guan Zhengyu Sun Guangci,The Plastic Surgery Hospital of Chinese Academy of Medical Sciences,Beijing 100041 |
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| Abstract: | The effect of retinoic acid on DNA synthesis of fibroblast was studied in vitro culture.The results demonstrated that retinoic acid significantly(P<0.01)inhi- bited the DNA synthesis of fibroblast in vitro culture and a dose-dependent relationship between DNA synthesis and retinoie acid concentration was observed.The possible mechanism of retinoic acid used for the treatment of sear was discussed. |
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| Keywords: | Retinoic acid Fibroblast Scar ~3H-TdR incorporation Cell culture |
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