Long-lasting stress, quantitative changes in nitric oxide concentration and functional state of brain mitochondria |
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| Authors: | Kuchukashvili Zurab Burjanadze George Menabde Ketevan Chachua Matrona Dachanidze Natalia Mikadze Mariam Koshoridze Nana |
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| Affiliation: | Department of Biology, Faculty of Exact and Natural Sciences, I. Javakhishvili Tbilisi State University, Tbilii, Georgia. zurabiku@gmail.com |
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| Abstract: | We have studied biochemical changes occurring in brain cell mitochondria of white rats on the background of stress induced by 30-day isolation and disruption of circadian rhythms. It was ascertained that due to long-lasting stress, there occurs activation of oxidative processes in mitochondria as well as inhibition of anti-oxidant system activity, causing development of energy deficiency in brain cells. The above-mentioned biochemical processes become the reason for activation and opening of the mitochondrial permeability transition pore (MPTP), which, in its turn, signals the start of neuroapoptosis and various neurodegenerative processes. |
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