| 长春西汀的大鼠在体肠吸收研究 |
| |
| 引用本文： | 聂淑芳,潘卫三,李伟,杜玍妮. 长春西汀的大鼠在体肠吸收研究[J]. 中国医药工业杂志, 2005, 36(10): 625-628 |
| |
| 作者姓名： | 聂淑芳 潘卫三 李伟 杜玍妮 |
| |
| 作者单位： | 沈阳药科大学药学系药剂教研室,辽宁,沈阳,110016 |
| |
| 摘 要： | 采用单向灌流技术考察长春西汀的大鼠在体肠吸收性质.结果表明,灌流速度对药物吸收速率常数(Ka)和表观吸收系数(Papp)有极显著影响(P＜0.01);药物浓度对Ka和Papp无显著影响(P＞0.05);药物在全肠道吸收较好,吸收窗主要在小肠,且小肠内无明显的特定吸收部位;羟丙基-β-环糊精在1%～4%范围内对药物的肠吸收无显著影响.
|
| 关 键 词： | 单向灌流法 长春西汀 在体肠吸收性质 |
| 文章编号： | 1001-8255（2005）10-0625-04 |
| 收稿时间： | 2004-07-12 |
| 修稿时间： | 2004-07-12 |
Study on in situ Intestinal Absorption of Vinpocetine in Rats |
| |
| NIE Shu-Fang,PAN Wei-San,LI Wei,DU Ga-Ni. Study on in situ Intestinal Absorption of Vinpocetine in Rats[J]. , 2005, 36(10): 625-628 |
| |
| Authors: | NIE Shu-Fang PAN Wei-San LI Wei DU Ga-Ni |
| |
| Abstract: | The in situ intestinal absorption property of vinpocetine in rats was investigated by means of single-pass intestinal perfusion technique. The results showed that perfusion flow rate could significantly affect the drug absorption constant(Ka) and apparent absorption coefficient(Papp) (P<0.01). Drug concentration had little effect on Ka and Papp(P>0.05). Vinpocetine could be absorbed well in general intestinal tract and especially in small intestine without specific absorption site. Vinpocetine in 1% to 4% hydroxypropyl-a-cyclodextrin had no significant effect on drug absorption. |
| |
| Keywords: | single-pass intestinal perfusion vinpocetine in situ intestinal absorption property |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
