| 放射性骨损伤愈合能力降低机制的实验研究 |
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| 引用本文： | 张艳玲,李建福,梁后杰.放射性骨损伤愈合能力降低机制的实验研究[J].肿瘤防治研究,2002,29(5):383-385. |
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| 作者姓名： | 张艳玲 李建福 梁后杰 |
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| 作者单位： | 1. 第三军医大学西南医院肿瘤科,重庆,400038
2. 第三军医大学西南医院骨科,重庆,400038 |
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| 摘 要： | 目的 探讨放射性骨损伤 (RBI)愈合能力降低的机制。方法 6 0 Coγ射线 15Gy单次照射并致兔右胫骨骨折 ,以半环槽氏外固定器固定 ,未照射组为对照组。术后 3d、1、3、6、12、2 4周通过组织学、血流量测定及免疫组化 (BMP与TGF β1)观察骨折愈合情况。结果 实验组骨折愈合较对照组晚 12～ 16周 ,且骨折端血流量明显降低 ;BMP与TGF β1的表达亦低于对照组。结论 RBI愈合能力下降的原因是骨组织血运障碍与抑制BMP与TGF \| β1的综合作用。
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| 关 键 词： | 放射性骨损伤 愈合 血流量 BMP TGF-β1 |
| 文章编号： | 1000-8578(2002)05-0383-03 |
| 收稿时间： | 2001-12-20 |
| 修稿时间： | 2001年12月20 |
Experimental study on the mechanism of decrease in bone healing capacity after irradiation |
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| ZHANG Yan-ling,LI Jian-fu,LIANG Hou-jie.Experimental study on the mechanism of decrease in bone healing capacity after irradiation[J].Cancer Research on Prevention and Treatment,2002,29(5):383-385. |
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| Authors: | ZHANG Yan-ling LI Jian-fu LIANG Hou-jie |
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| Institution: | ZHANG Yan-ling,LI Jian-fu,LIANG Hou-jie Department of Oncology,South West Hospital,the Third military Medical University,Chongqing 400038,China |
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| Abstract: | Objective To investigate the mechanism of decrease in bone healing capacity after irradiation.Methods After the right hind shank of rabbits was irradiated with 60 Co γ ray at a dose of 15Gy,. the transverse fracture of the upper\|middle tibia was inflicted with electric saw. Then, the Half\|ring External Fixator was placed. Unirradiation group was called the control group. The therapeutic effects were observed with histological examination, BMP\|McAb and TGF\|β1\|McAb immunohistochemistry, measuremen... |
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| Keywords: | BMP |
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