Amino acid sequence and function of a new alpha-toxin from the Amazonian scorpion Tityus cambridgei. |
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Authors: | Anna Rosa Murgia Cesar V F Batista Gianfranco Prestipino Lourival D Possani |
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Affiliation: | Istituto di Biofisica, C.N.R., via De Marini 6, 16149 Genoa, Italy. |
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Abstract: | A toxic peptide earlier denominated Tc48b [Toxicon 40 (2002) 557] was purified to homogeneity and its amino acid sequence determined. It has 64 amino acid residues stabilized by four disulfide bridges with a molecular weight of 7,385.2 atomic mass units (a.m.u.). It affects Na(+)-permeability in pituitary GH3 cells in culture, in a similar fashion as those reported for alpha-scorpion toxins, contrary to most of the New World scorpion toxins that are beta-toxins. |
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Keywords: | Amino acid sequence Na+-channel Patch-clamp Scorpion toxin Tityus cambridgei |
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