2型糖尿病幽门螺杆菌感染情况分析

目的 了解2型糖尿病(T2DM)患者幽门螺杆菌(Hp)感染情况,初步探讨Hp与T2DM的关系.方法 768例住院T2DM患者[T2DM组,其中新诊断T2DM 194例(新诊组),再诊断T2DM 574例(再诊组)]及健康查体者172例(对照组)行14C尿素呼气试验,分别比较T2DM组和对照组间总Hp感染率、不同性别间Hp感染率;新诊组及再诊组间总Hp感染率;不同年龄段T2DM组患者不同性别间Hp感染率.结果 T2DM组总Hp感染率高于对照组[56.0%(430/768)比37.8%(65/172),P<0.01],T2DM组与对照组同性别Hp感染率比较差异均有统计学意义(P<0.01).新诊组与再诊组间总Hp感染率、不同性别间Hp感染率比较差异无统计学意义(P>0.05).不同年龄段T2DM组患者不同性别间Hp感染率比较差异无统计学意义(P>0.05).结论 T2DM患者Hp感染率高于非糖尿病者,Hp感染与T2DM有密切关系,与患者年龄、性别、病程无关.

Analysis of Helicobacter pylori infection status in type 2 diabetes mellitus

Objective To comprehend the status of Helicobacter pylori (Hp) infection in type 2 diabetes mellitus (T2DM) patients, and study the relationship between Hp and T2DM. Methods Seven hundred and sixty-eight in-hospital T2DM patients (T2DM group, including new diagnosed 194 patients and re-diagnosed 574 patients) and 172 sex, age matched health individuals(control group ) were involved in this study. 14C-urea breath test (14C-UBT) was proceeded in both groups to determine Hp infection, and infection rates were calculated. Results Total Hp infection rate in T2DM group was significantly higher than that in control group [56.0%(430/768) vs 37.8%(65/172) ,P< 0.01], delamination analysis according to sex also showed significant differences between T2DM group and control group(P < 0.01). The rate of Hp infection in new diagnosed patients and re-diagnosed patients, female patients and male patients had no significant difference (P > 0.05 ). The rate of Hp infection in different age and sex had no significant difference (P >0.05 ). Conclusions The rate of Hp infection in T2DM patients is higher than that in non-T2DM patients.Hp infection has relationship with T2DM, and has no relationship with age, sex and course of disease.