慢性肾功能衰竭患者外周血细胞CD146的表达及意义

目的 探讨CD146在慢性肾功能衰竭（CRF）患者外周血细胞中的表达及意义.方法 收集本院2007年8月至2009年7月门诊及住院CRF患者51例为CRF组,33例正常人为健康对照组,流式细胞术检测两组外周血细胞CD146的表达并比较两组之间的差异,分析CRF患者外周血细胞CD146表达与血尿素氮（BUN）、血肌酐（Scr）的相关性.结果 与对照组比较,CRF组单核细胞、中性粒细胞CD146＋细胞百分率及CD45-CD146＋细胞数量均显著升高[（4.09±3.48）%比（0.20±0.10）%;（4.71±3.94）%比（0.79±0.14）%;（16.43±10.48）个/μl比（2.16±0.81）个/μl,均P〈0.001].CRF患者外周血CD45-CD146＋细胞数量与BUN、Scr均呈正相关（r=0.480、0.595,均P〈0.01）.结论 外周血单核细胞及中性粒细胞CD146的表达及升高与CRF的发生有关,CD45-CD146＋细胞数量增加与CRF的发生及严重程度有关.

Clinical significance and expression of CD146 on peripheral blood cells in patients with chronic renal failure

Objective To study the clinical significance and expression of CD146 on peripheral blood cells in patients with chronic renal failure （CRF）. Methods Expression of CD146 in peripheral blood samples from 51 ambulatory or hospitalized patients with CRF （registered between August 2007 and July 2009 to our hospital） and from 33 normal controls were determined and compared between two groups. Correlation of peripheral blood CD146 with blood urea nitrogen （BUN） , and serum creatinine （Scr） in patients with CRF was analyzed. Results Compared with normal controls, the rate of CD146＊ on monocyte and neutrophile in patients with CRF were significantly higher [ （4.09±3.48）% vs （0.20±0.10）% ;（4.71± 3.94）% vs （0.79±0.14）% , both P〈0.001], and the number of CD45-CD146＊ cells in patients with CRF was obviously higher [ （16.43±10.48） /μl vs （2.16±0.81 ）/μl,P〈0.001） ]. The number of CD45-CD146＋ cells in patients with CRF was positively correlated with BUN and Scr （r=0.480 and 0.595, both P〈0.01）. Conclusions Correlation between increased CD 146 on monocyte or neutrophile and the pathogenesis of CRF is found. The increase in CD45-CD146＋ cell numbers is correlated with the pathogenesis and severity of CRF.