川楝素对大白鼠膈肌神经肌肉接头超微结构的影响

本实验用电子显微镜观察了大鼠肌注川楝素后,膈肌神经肌肉接头超微结构的改变。给药后3小时,在突触前看到明显的结构改变,主要是突触小泡数量显著减少。其次是长管形泡增多、自噬体样结构经常出现,以及线粒体较分散、较趋近于突触前膜等。川楝素对突触后结构的影响则不明显。仅看到部分神经肌肉接头在接头区有肌原纤维Z-线消失和Schwann细胞突起伸入突触间隙的现象。本实验可能为阐明川楝素的作用机理提供了一点形态学依据。

EFFECT OF TOOSENDANIN ON THE ULTRASTRUCTURE OF THE RAT NEUROMUSCULAR JUNCTION

Toosendanin is a principle extracted from the bark of Melia toosendan Sieb et Zucc. It is used as an ascaricide.Some definite ultrastructural changes were observed in the nerve terminals of the diaphra gmatic neuromuscular junction after intramuscular injection of toosendanin in rats. The changes included a noticeable decrease in the number of synaptic vesicles and an increase in the number of elongated vesicles. Furthermore, it was found that the phagosome-like structure occured frequently and the mitochondria appeared to be more scattered.The results are discussed in relation to the possible mode of action of toosendanin.