吸烟对男性精子核DNA完整性的影响

目的探讨吸烟对男性精液质量及精子核DNA完整性的影响。方法 120例男性不育患者根据吸烟习惯和烟龄分为3组:A组日吸烟量小于10支,且烟龄不超过1年;B组日吸烟量10～20支,且烟龄5～10年;C组日吸烟量大于或等于20支,且烟龄大于或等于10年。选用35例已生育健康男性作为对照。对其精液常规参数及DNA片段化指数(DFI)值进行检测。结果不育吸烟组精子活力显著低于不育非吸烟组,DFI值显著增高;A、B、C3组比较,C组精子活力显著低于B组和A组,DFI值显著增高。结论吸烟可以破坏精子核DNA完整性,严重影响精液质量。

Influence of cigarette smoking on sperm DNA integrity

Objective To explore the impact of smoking on sperm DNA integrity.Methods 120 infertile men were divided into 3 groups according to smoking quantity and duration.The group A：daily smoking 10 cigarettes and smoking age ≤1 year; the group B：daily smoking 10-20 cigarettes and smoking age 5-10 years; the group C：daily smoking ≥20 cigarettes and smoking age ≥10 years.35 cases of healthy men having child were recruited as control in the study.The parameters of their semen and sperm DFI were detected.Results The sperm motility in the infertile smoker group was significantly lower than that in the infertile non-smoker group and sperm DFI was significantly increased; in the group C,sperm motility was significantly lower than that in the group B and group A,while the DFI was significantly increased.Conclusion Smoking can influence the sperm DNA integrity and seriously affect the quality of semen.