| 增龄与心力衰竭的研究进展 |
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| 引用本文： | 赵阳,商鲁翔,汤宝鹏.增龄与心力衰竭的研究进展[J].中华老年多器官疾病杂志,2021,20(8):623-627. |
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| 作者姓名： | 赵阳 商鲁翔 汤宝鹏 |
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| 作者单位： | 新疆医科大学第一附属医院起搏电生理科·新疆心电生理与心脏重塑重点实验室,乌鲁木齐 830054,山东第一医科大学第一附属医院·山东省千佛山医院心内科,济南 250014,新疆医科大学第一附属医院起搏电生理科·新疆心电生理与心脏重塑重点实验室,乌鲁木齐 830054 |
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| 基金项目： | 国家重点研发计划(2016YFC0900905) |
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| 摘 要： | 心力衰竭(简称心衰)发病率及患病率随年龄增加而逐渐升高,研究显示增龄可独立于其他疾病造成心肌损伤,最终导致心衰发生。本文综述了增龄导致心脏的结构、功能及表型变化,着重叙述了增龄导致心衰的机制研究进展,包括心肌细胞衰老、血管衰老、细胞外基质重塑、神经内分泌失衡及非编码RNA改变等,并介绍了几种针对增龄性心衰的新兴治疗措施。
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| 关 键 词： | 衰老 心力衰竭 衰老心血管事件链 致病机制 |
| 收稿时间： | 2020/8/21 0:00:00 |
Research progress in aging and heart failure |
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| ZHAO Yang,SHANG Lu-Xiang and TANG Bao-Peng.Research progress in aging and heart failure[J].Chinrse journal of Multiple Organ Diseases in the Elderly,2021,20(8):623-627. |
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| Authors: | ZHAO Yang SHANG Lu-Xiang and TANG Bao-Peng |
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| Abstract: | The incidence and prevalence of heart failure (HF) gradually increase with age. Studies have shown that aging can cause myocardial injury independent of other diseases and eventually lead to HF. This article reviews structural, functional and phenotypic changes of heart caused by aging with emphasis on the research progress in the mechanism of HF caused by aging, including cardiomyocyte senescence, vascular senescence, extracellular matrix remodeling, neuroendocrine imbalance, and non-coding RNA changes. It also introduces several new therapeutic measures for aging-related HF. |
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| Keywords: | aging heart failure aging cardiovascular continuum pathogenic mechanism This work was supported by National Key Research & Development Program of China |
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