| 加强药物基因组学研究报告规范（STROPS）及解读 |
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| 引用本文： | 鲁欣然,赖雪峰,孙凤,詹思延,王胜锋. 加强药物基因组学研究报告规范（STROPS）及解读[J]. 中华流行病学杂志, 2022, 43(5): 747-754 |
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| 作者姓名： | 鲁欣然 赖雪峰 孙凤 詹思延 王胜锋 |
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| 作者单位： | 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191;北京大学公共卫生学院流行病与卫生统计学系, 北京 100191;北京大学第三医院临床流行病学研究中心, 北京 100191 |
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| 基金项目： | 国家自然科学基金(81502884);国家重点研发计划(2018YFC1311704) |
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| 摘 要： | 药物基因组学研究旨在探究遗传变异与药物的疗效和不良反应之间的关联，对样本量有很高的要求。为有效进行Meta分析以探究药物遗传关联，亟需提高药物基因组学研究报告质量。2020年制定的加强药物基因组学研究报告规范（Strengthening the Reporting of Pharmacogenetic Studies，...
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| 关 键 词： | 药物基因组学研究报告规范 条目清单 解读 |
| 收稿时间： | 2021-04-02 |
Strengthening the Reporting of Pharmacogenetic Studies (STROPS) guideline |
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| Lu Xinran,Lai Xuefeng,Sun Feng,Zhan Siyan,Wang Shengfeng. Strengthening the Reporting of Pharmacogenetic Studies (STROPS) guideline[J]. Chinese Journal of Epidemiology, 2022, 43(5): 747-754 |
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| Authors: | Lu Xinran Lai Xuefeng Sun Feng Zhan Siyan Wang Shengfeng |
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| Affiliation: | Department of Epidemiology and Biostatistics School of Public Health, Peking University, Beijing 100191, China;Department of Epidemiology and Biostatistics School of Public Health, Peking University, Beijing 100191, China;Center for Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China |
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| Abstract: | Pharmacogenetic studies are designed to investigate the associations between genetic variation and treatment response for a particular drug in terms of both efficacy and adverse events and have high sample size requirements. To improve the quality of pharmacogenetic studies and facilitate the Meta-analyses to investigate statistically significant associations, Strengthening the Reporting of Pharmacogenetic Studies (STROPS) guideline was developed in 2020 based on the Strengthening the Reporting of Genetic Association Studies (STREGA) statement. The objective of this article is to present a brief introduction to the STROPS guideline and an interpretation of the key points in some items with examples for the better understanding and application. |
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| Keywords: | Strengthening the Reporting of Pharmacogenetic Studies Guideline Checklist Interpretation |
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