我国艾滋病患者的死亡趋势及其相关危险因素分析

目的:描述我国报告艾滋病患者中死亡病例基本特征及其变化趋势，并研究导致死亡的危险因素，为艾滋病防治策略的制定提供线索和依据。方法:从我国艾滋病防治基本信息系统下载数据库，筛选病程为“艾滋病”患者，描述其死亡数及死亡比例随时间变化趋势，并采用Cox比例风险模型分析死亡的相关危险因素。结果:截至2019年12月31日，我国...

Analysis on death trend in AIDS patients and related risk factors in China

Objective To understand the basic characteristics of death cases,analyze the death trends in AIDS patients and the risk factors in China and provide evidence for the development of AIDS prevention and control strategy.Methods The data were collected from the national basic information system of HIV/AIDS.The information of the cases in AIDS phase were used.The death number and mortality trends in AIDS cases were described,and Cox Proportion Hazards Regression Model was constructed to assess hazard ratios(HR)for independent variables.Results By the end of 2019,a total of 582472 AIDS cases,including 168391 deaths,had been reported in China.Among the death cases,males accounted for 76.8%(129343/168391),heterosexual contact was the main transmission route,accounting for 60.9%(102516/168391).The proportion of the death cases who had ever received ART was 54.0%(90888/168391).The inter-quartile(P₂₅,P₇₅)of first CD4+T cells counts(CD4)was 34 cells/μl,240 cells/μl.Up to 43.5%(73191/168391)of the deaths occurred within one year after diagnosis.From 2007 to 2019,the annual death number increased from 5485 to 18737,the mortality rates decreased form 10.9%%to 4.3%.The average time interval from diagnosis to death ranged from 1.4 year to 4.0 years,showing increase trend by year.The results of Cox regression analysis showed that older age(50-years old:HR=1.50;≥65 years old:HR=2.00),being male(HR=1.44)、being in minority ethnic group(HR=1.10),having lower first CD4 levels(0-cells/μl,HR=2.73;200-cells/μl,HR=1.33;350-cells/μl,HR=1.13),heterosexual transmission route(HR=1.64)and injecting drug use(HR=1.79)were the risk factors related to deaths in AIDS patients.The higher educational levels(junior middle school:HR=0.86,senior high school and above:HR=0.59)and receiving antiviral treatrment(HR=0.09)were protective factors.Conclusions The number of death cases increased,meanwhile the mortality rates decrease year by year in AIDS patients in China during 2007-2019.It is necessary to strengthen the early detection and treatment of AIDS to reduce the mortality.