鸡蛋摄入与非酒精性脂肪肝病患病风险的病例对照研究

目的 探讨鸡蛋摄入与非酒精性脂肪肝病（non-alcoholic fatty liver disease，NAFLD）患病风险的关系，为NAFLD的防控提供流行病学依据。 方法 收集2015年4月―2017年8月在南平市第一医院体检中心进行健康检查的体检者数据，以腹部彩超确诊的541名病例和按年龄性别随机抽取的541名对照进行病例对照研究。采用统一编制的结构式调查问卷及半定量食物频数问卷面对面调查研究对象的一般行为特征及膳食摄入情况。多因素非条件Logistic回归分析模型计算OR值及其95%CI，探索鸡蛋摄入与NAFLD患病风险的关系。 结果 与每天摄入鸡蛋相比，鸡蛋摄入频率为0患NAFLD的风险增高，其调整的OR值及其95% CI为1.86（95% CI：1.10~3.15）。敏感分析结果及亚组分析均显示从不摄入鸡蛋仍然是NAFLD的危险因素。 结论 从不摄入鸡蛋可能增高NAFLD的患病风险。

A case-control study on the association between egg consumption and risk of non-alcoholic fatty liver disease

  Objective   To explore the association between egg consumption and risk of non-alcoholic fatty liver disease(NAFLD).   Methods   We conducted a retrospective case-control study including 541 patients diagnosed with NAFLD and 541 controls matched by sex and age from the Affiliated Nanping First Hospital of Fujian Medical University in Nangping City. Information on dietary intake was collected using a semiquantitative food frequency questionnaire and egg consumption was calculated. Binary Logistic regression model was used to estimate OR and the 95% confidence interval (95% CI) was for the association between egg consumption and NAFLD risk.   Results   Compared with 7 times/week egg consumption, non-egg consumers was associated with higher risk of NAFLD, and the adjusted ORs and 95% CI 1.86 (95%CI:1.10-3.15). The sensitivity analyses and stratified analysis results showed that non-egg consumers was significantly associated with risk of developing NAFLD.   Conclusions   Non-egg consumption was significantly associated with higher risk of NAFLD, largely independent of other risk factors.