中国健康人群水痘-带状疱疹病毒抗体水平的Meta分析

目的:本文旨在系统分析和评价中国健康人群水痘-带状疱疹病毒（VZV）IgG抗体水平。方法:系统检索CNKI、万方、CBM以及PubMed数据库有关中国健康人群VZV IgG抗体水平的研究，检索时限为2000年1月1日至2020年11月3日。使用澳大利亚循证卫生保健中心Joanna Briggs Institute（JB...

A Meta-analysis on varicella-zoster virus antibody levels in healthy population in China

Objective To systematically analyze and evaluate the IgG antibody levels of varicella-zoster virus (VZV) in healthy population in China. Methods CNKI, Wanfang, CBM and PubMed databases were used for the retrieval of literatures about VZV IgG antibody levels in healthy people in China from January 1, 2000 to November 3, 2020. The quality of the included papers was evaluated by the critical appraisal tools for cross sectional study from Joanna Briggs Institute (JBL). The stratified analysis on the IgG antibody levels in populations in different age groups, provinces, regions, gender groups, and years was performed by using software Stata 14.0. Results A total of 59 papers were included that met the inclusion criteria, including 51 papers in Chinese and 8 papers in English. There were 22 papers with quality score of 8, 16 papers with quality score of 7, 15 papers with quality score of 6, and 6 papers with quality score of 5. Meta-analysis showed that the positive rate of VZV IgG antibody in healthy population in China was 64% (95%CI:60%-67%, I²=98.7%), and the IgG antibody levels were reported in the papers for 22 provinces of China. The positive rate of VZV IgG antibody was highest in Yunnan (79%, 95%CI:64%-93%, I²=94.7%) and lowest in Inner Mongolia (50%, 95%CI:46%-54%); the positive rate of VZV IgG antibody was highest in Northeastern China (71%, 95%CI:69%-73%) and lowest in Eastern China (62%, 95%CI:57%-67%); the positive rate of VZV IgG antibody in urban population was higher than that in rural population (RR=1.08, 95%CI:1.04-1.11). The positive rate of VZV IgG antibody in women was higher than that in men (RR=1.10, 95%CI:1.08-1.11); the positive rate of VZV IgG antibody in the population increased with age; and the positive rate of VZV IgG antibody increased with the change of sampling time. Conclusion The positive rate of VZV IgG antibody in healthy population in China was relatively low; the coverage of varicella vaccine should be improved for the outbreak control and incidence reduction of varicella in China.