瞬时受体电位通道在心脏纤维化中作用的研究进展

心脏纤维化参与多种心脏疾病的发生发展,可导致心脏重塑和功能障碍,最终引起心力衰竭甚至死亡。心脏成纤维细胞异常增殖并分化为心脏肌成纤维细胞以及心脏细胞外基质过度沉积等是心脏纤维化的主要病理基础。瞬时受体电位(TRP)通道是一种非选择性的阳离子通道,主要介导Ca2+内流来调节细胞功能。越来越多的研究表明,在心肌中TRP通道除调控多种生理功能外,同时参与心脏纤维化的发生发展。本文主要对心脏纤维化的发生机制及TRP通道作为治疗心脏纤维化的新靶点进行综述。

Research progress in roles of transient receptor potential channels in cardiac fibrosis

Cardiac fibrosis is involved in the occurrence and development of various cardiac diseases,leading to cardiac remodeling,dysfunction,heart failure and even death.The pathological bases of cardiac fibrosis are the proliferation and differentiation of cardiac fibroblasts and the excessive deposition of extracellular matrix.Transient receptor potential(TRP)channels are non-selective cationic channels,regulating cell functions mainly via Ca2+influx.Increasing studies have shown that TRP channels are involved in the regulation of many physiological functions and the occurrence and development of cardiac fibrosis.This article reviews the mechanism of cardiac fibrosis and TRP channels seen as a new target for its treatment.