雌激素对外周血白细胞端粒长度的影响

端粒随着每个细胞分裂而缩短,白细胞端粒长度(LTL)和端粒酶在多种疾病中被广泛研究,如心血管疾病及其相关代谢危险因素、神经系统疾病、恶性肿瘤等。端粒长度的变化可能由多种因素决定,包括遗传和环境因素等。出生时,男性和女性的端粒长度差异不明确,而成年女性的端粒普遍比男性长,这种性别差异可能与内源性雌激素暴露或激素替代治疗(HRT)之间存在关联。雌激素具有抗氧化、提高端粒酶活性的作用,了解其相关性有助于探索以端粒-端粒酶系统为靶点治疗年龄相关性疾病的方法。

Effect of estrogen on telomere length in peripheral blood leukocytes

Telomeres undergo attrition with each cell division. Leukocyte telomere length (LTL) and telomerase activity have been extensively investigated in a variety of diseases, such as cardiovascular disease and related metabolic risk factors, neurological disorders, and malignancies. Telomere length may be determined by various factors, including the genetic load and environmental factors. At birth, gender difference in the telomere length is not significant, but telomeres are longer in women than in men. This gender discrepancy is probably caused by the effects of endogenous estrogen exposure or hormone replacement treatment (HRT). Estrogen is known to be antioxidant and may increase telomerase activity; therefore, knowledge about the associate between estrogen and telomere length helps explore therapies targeting the telomere-telomerase system as promising treatment for age-related diseases.