兰州市2010—2019年丙型肝炎流行特征

  目的  分析兰州市丙型肝炎（hepatitis C，HCV）流行特征及其变化趋势，为HCV防控措施的制定提供科学依据。  方法  收集2010-2019年兰州市HCV报告病例资料，采用Excel 2016、SPSS 21.0软件进行资料整理与统计，采用Joinpoint 4.7.0.0软件进行HCV年报告发病率趋势分析。  结果  2010-2019年兰州市累计报告HCV病例22 697例，年均报告发病率为70.20/10万，Joinpoint回归模型结果显示，2010-2019年兰州市HCV年报告发病率整体呈平缓下降趋势，年度变化百分比（annual percent change，APC）为-7.49%（95%CI:-9.5%~-5.4%）。全年均有发病，无季节性增多；年均报告发病率排在前三的县（区）是城关区（59.79/10万）、七里河区（59.04/10万）和安宁区（43.46/10万）。报告病例男女性别比为1.06:1，病例主要集中在35~79岁之间，且发病率随着年龄的增加而逐渐上升，职业主要以农民和离退人员为主。  结论  兰州市HCV病例报告例数及年报告发病率整体呈下降趋势。应加强重点人群及地区疫情检测，继续规范病例诊断与报告制度。

Epidemic characteristics of hepatitis C in Lanzhou City from 2010 to 2019

  Objective  To analyze the epidemiological characteristics and trend of hepatitis C in Lanzhou City, so as to provide scientific evidence for the strategy of prevention and control.  Methods  Data of hepatitis C virus infection reported cases in Lanzhou City from 2010 to 2019 were collected and analyzed by Excel 2016, SPSS 21.0 and Joinpoint 4.7.0.0 software.  Results  22 697 cases of hepatitis C were reported in Lanzhou city from 2010 to 2019, the annual average incidence rate was 70.20/100 000. The results of Joinpoint regression models showed that the incidence of rates hepatitis C in Lanzhou City were decreased at an average annual percent changes (APC) of 7.49% (95% CI:-9.5% to -5.4%).The time distribution of onset was steady without seasonality. The three district with the highest reported incidence rates were Chengguan District (59.79/100 000), Qilihe District (59.04/100 000) and Anning District (43.36/100 000). The reported gender ratio was 1.06:1. The ages of onset were mainly from 35 to 79 years old, and the incidence of hepatitis C increased gradually with age. The occupational composition was mainly for farmers and retirees.  Conclusions  The number of reported cases and annual reported incidence of hepatitis C in Lanzhou show decreasing trends. It is necessary to strengthen the surveillance of key populations and areas, standardize the case report, and raise public awareness of hepatitis C virus infection.