广州市自然人群病毒性肝炎血清流行病学研究

目的了解广州市自然人群病毒性肝炎的血清流行病学特征。方法采取分层多级整群系统随机抽样方法抽取研究对象，对其作流行病学个案调查，并应用酶联免疫吸附试验（ELISA法）检测病毒性肝炎各感染标志物。结果广州市自然人群HAV、HBV、HCV、HDV、HEV、HGV感染率分别为74．47％、64．10％、0．65％、0．13％、1．69％和0．65％；HAV、HBV和HEV的感染率在老城区、新城区和郊市区中的差异有高度显著性意义（P〈0．01），而HCV、HDV和HGV的差异无显著性意义（P〉0．05）；HBV感染率在男女之间差异有高度显著性意义（P〈0．01），HCV感染率在男女之间差异有显著性意义（P〈0．05），而HAV、HDV、HEV和HGV的感染率则无性别差异（P〉0．05）；HAV、HBV、HCV、HDV、HEV、HGV最低感染年龄分别为2岁、2岁、20岁、31岁、5岁和13岁，最高感染年龄分别为90岁、86岁、46岁、67岁、74岁和71岁；HAV、HBV和HEV感染率均与年龄呈正相关（P〈0，01、P〈0，01和P〈0．05）。结论广州市自然人群各型病毒性肝炎感染具有不同的流行病学特征，其中HAV和HBV的感染率较高，HCV、HDV、HEV和HGV的感染水平则较低。

A study on seroepidemiology of viral hepatitis among population in Guangzhou

Objective To investigate the seroepidemiological features of viral hepatitis among population in Guangzhou. Methods The subjects were selected by multi-stage cluster random sampling.Then individual epidemical investigation was conducted and infection markers were tested with ELISA in all the subjects.Results The infection rates of HAV.HBV,HCV,HDV,HEV and HGV were 74.47%,64.10%,0.65%,0.13%,1.69% and 0.65%,respectively.There were statistical differences in the infection rates of HAV,HBV and HEV except for HCV,HDV and HGV among the old downtown,new downtown and suburb areas (P<0.01).The infection rate of HBV anti that of HCV were significantly different between the male subjects and female ones (P<0.01 and 0.05).The youngest case of the infection of HAV,HBV,HCV,HDV,HEV and HGV was 2,2,20,31,5 and 13 years old while that of the eldest case was 90,86,46,67,74 and 71 years old,respectively.The infection rates of HAV,HBV and HEV were positively correlated to age (P<0.01,0.01 and 0.05).Conclusions The epidemical features of different types of viral hepatitis are different among the population in Guangzhou.The infection rates of HAV and HBV are higher but those of HCV,HDV,HEV and HGV are lower.