| 高效液相色谱法测定复方阿司匹林片中阿司匹林的溶出度 |
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| 引用本文： | 宋小莉, 张文伟. 高效液相色谱法测定复方阿司匹林片中阿司匹林的溶出度[J]. 中国现代应用药学, 2003, (4): 308-310. |
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| 作者姓名： | 宋小莉 张文伟 |
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| 作者单位： | 1. 浙江省邵逸夫医院,浙江,杭州,310016
2. 杭州民生药业集团产品开发部,浙江,杭州,310012 |
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| 摘 要： | 目的 建立复方阿司匹林片中低浓度阿司匹林的溶出度测定方法。方法 采用将溶出液中的阿司匹林全部水解成水杨酸后用高效液相色谱法测定。结果 该法消除了复方成分双嘧达莫的干扰。结论 该法操作简便,结果正确。
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| 关 键 词： | 复方阿司匹林片 阿司匹林 溶出度 测定 |
| 文章编号： | 1007-7693(2003)04-0308-03 |
Determination of Asprin dissolution in compound Asprin tablets by HPLC |
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| SONG Xiao-Li, ZHANG Wen-Wei. Determination of Asprin dissolution in compound Asprin tablets by HPLC[J]. Chinese Journal of Modern Applied Pharmacy, 2003, (4): 308-310. |
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| Authors: | SONG Xiao-Li ZHANG Wen-Wei |
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| Abstract: | OBJECTIVE To establish the dissolution determination method of low dose asprin in compound asprin tablets. METHOD An HPLC method was developed to determine the salicylic acid, a product after hydrolysis of asprin.RESULTS The average recovery ratio and RSD for asprin were 100.2% and 1.2% respectively. CONCLUSION This method is simple, rapid and accurate. |
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| Keywords: | compound asprin tablets asprin dissolution determination |
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