| 人催乳素受体拮抗剂G129R-hPRL在乳腺肿瘤治疗中的研究进展 |
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| 引用本文： | 顾丽,张君,苏燕.人催乳素受体拮抗剂G129R-hPRL在乳腺肿瘤治疗中的研究进展[J].中国现代应用药学,2011,28(1):30-34. |
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| 作者姓名： | 顾丽 张君 苏燕 |
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| 作者单位： | 内蒙古科技大学包头医学院，a.病原生物学教研室,内蒙古 包头 014060;生物化学与分子生物学教研室，内蒙古 包头 014060;生物化学与分子生物学教研室，内蒙古 包头 014060 |
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| 基金项目： | 内蒙古自治区自然科学基金项目(200711020913) |
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| 摘 要： | 目的 介绍特异性人催乳素(PRL)受体拮抗剂G129R-hPRL在乳腺肿瘤治疗中的研究进展.方法 查阅近年采国内外相关文献进行总结和归纳,对G129R-hPRL的功能、作用机制、优缺点、改进措施以及在乳腺肿瘤治疗中的应用和今后的发展方向进行综述.结果 G129R-hPRL通过竞争性拮抗内源性PRL的作用进而抑制乳腺癌细...
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| 关 键 词： | 催乳素 催乳素受体拮抗剂 G129R-hPRL 乳腺肿瘤 |
| 收稿时间： | 4/6/2010 12:00:00 AM |
Advances in the Research of Human Prolactin Receptor Antagonists G129R-hPRL in Breast Cancer Therapy |
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| GU Li,ZHANG Jun and SU Yan.Advances in the Research of Human Prolactin Receptor Antagonists G129R-hPRL in Breast Cancer Therapy[J].The Chinese Journal of Modern Applied Pharmacy,2011,28(1):30-34. |
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| Authors: | GU Li ZHANG Jun and SU Yan |
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| Institution: | Baotou Medical College, Inner Mongolia University of Science and Technology, a.Department of Pathogenic Organism, Baotou 014060, China;Department of Biochemistry Andmolecular Biology, Baotou 014060, China;Department of Biochemistry Andmolecular Biology, Baotou 014060, China |
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| Abstract: | OBJECTIVE To introduce the progress of specific human prolactin receptor antagonist G129R-hPRL in breast cancer therapy research. METHODS Review the function, mechanism, advantages and disadvantages, improvements, the application and the prospect of the prolactin receptor antagonist G129R-hPRL in therapy of breast tumor through searching and summarizing relevant literatures. RESULTS G129R-hPRL can inhibit proliferation, mediate apoptosis of breast cancer cell and play the role of anti-breast cancer by competitively antagonize endogenous prolactin. G129R-hPRL-based multi-functional fusion protein, as well as combination G129R-hPRL with other anti-tumor component also shows a stronger tumor suppressor effect. CONCLUSION G129R-hPRL is expected to be an ideal drug in treatment and prevention of breast cancer. |
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| Keywords: | prolactin prolactin receptor antagonist G129R-hPRL breast tumor |
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