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Colony-Stimulating Factor Producing Carcinoma of the Gallbladder |
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| Authors: | SAKAMOTO, KIYOSHI EGAMI, HIROSHI YOSHIMURA, RYUTA NAKAMURA, SHUJI IKEI, SATOSHI MORI, KATSUTAKA MATSUMOTO, MAKOTO AKAGI, MASANOBU |
| Affiliation: | 1Department of Surgery II, Kumamoto University Medical School Kumamoto 2Departments of Immunopathology, Kumamoto University Medical School Kumamoto 3The Institute of Cancer Research, Kagoshima University Medical School Kagoshima |
| Abstract: | A patient with an anaplastic carcinoma of the gallbladder accompaniedby marked neutrophilia was found to have high colony-stimulatingfactor (CSF) activity in the urine and serum. The supernatantof the cultured tumor cells (6th passage) showed high and specificCSF activity. These specimens induced the formation of granulocytecolonies, macrophage colonies or granulocyte macrophage mixedcolonies by both human and C57BL mouse bone marrow cells insoft agar. These results suggest that this tumor is a human granulocyte-macrophage(GM)-CSF producing tumor. |
| Keywords: | CSF Carcinoma Gallbladder Neutrophilia |
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