| 阿尔茨海默病的多模态影像学研究进展 |
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| 引用本文： | 吴应行,;陈自谦.阿尔茨海默病的多模态影像学研究进展[J].医学综述,2014(11):2033-2036. |
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| 作者姓名： | 吴应行 ;陈自谦 |
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| 作者单位： | [1]福建医科大学福总临床医学院,福州350025; [2]南京军区福州总医院医学影像中心,福州350025 |
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| 基金项目： | 福建省工业、农业和社会发展科技重点项目（2012Y0057） |
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| 摘 要： | 阿尔茨海默病(AD)是一种以进行性的认知障碍、行为改变和记忆力减退为主要特征的神经变性疾病,AD的发病机制目前尚不明确,尸检结果揭示了AD的主要病理特征是淀粉样蛋白沉积、神经纤维缠结和老年斑的形成等。多模态影像技术可对AD的结构、功能及代谢情况进行评价,有利于对其早期诊断及病理生理学进行进一步的研究,多模态影像学在AD的诊断及鉴别诊断中的作用也越来越显著。
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| 关 键 词： | 阿尔茨海默病 结构影像学 功能影像学 代谢影像学 |
Research Advances in Multimodality Imaging of Alzheimer Disease |
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| Affiliation: | WU Ying-hang , CHEN Zi-qian ( 1. Fuzong Clinical School of Fujian Medical University, Fuzhou 350025, China ; 2. Medical Imaging Center, Fuzhou General Hospital of Nanfing Command, Fuzhou 350025, China) |
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| Abstract: | Alzheimer disease（AD） is a neurodegenerative disease of the brain associated with irreversi- ble cognitive decline, behavioral changes, and memory impairment. The pathogenesis of AD is unknown, and autopsy results revealed that the main pathological features of AD is β-amyloid deposition, neumfibrillary tangles and senile plaques, etc. Multimodality imaging techniques can assess the structure, function and metabolism of AD, and it is beneficial to the further study of early diagnosis and patbophysiology of AD. Here is to make a review of the muhimodality imaging research advances in AD. |
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| Keywords: | Alzheimer disease Structural imaging Functional imaging Metabolic imaging |
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