| 脑缺血/再灌注神经元钙离子通道的研究进展 |
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| 引用本文： | 石咏梅,;葛金文. 脑缺血/再灌注神经元钙离子通道的研究进展[J]. 医学综述, 2014, 0(14): 2507-2509 |
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| 作者姓名： | 石咏梅, 葛金文 |
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| 作者单位： | [1]湖南中医药大学中医学院解剖教研室,长沙410208; [2]湖南中医药大学中西结合学院,长沙410208 |
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| 基金项目： | 湖南省教育厅一般项目（13C699） |
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| 摘 要： | 脑缺血/再灌注损伤主要与自由基过度形成、兴奋性氨基酸毒性作用、炎性反应、细胞内Ca2+超载及细胞凋亡等密切相关,其中Ca2+超载及其触发的一系列有害代谢反应是导致脑缺血/再灌注时神经元损伤和死亡的关键因素。该文通过总结生理情况下神经元胞内外的钙离子通道和缺血再灌注时神经元钙离子通道的变化,揭示脑缺血/再灌注时神经元钙超载的机制,为临床脑缺血类疾病的治疗提供新的靶点。
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| 关 键 词： | 脑缺血/再灌注损伤 钙离子通道 神经元 |
Research Progress of Calcium Channels in the Neuron after Cerebral Ischemia/Reperfusion Injury |
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| Affiliation: | SHI Yong-mei , GE Jin-wen ( 1. Department of Anatomy, Traditional Chinese Medicine College of Traditional Chinese Medicine University of Hunan, Changsha 410208, China; 2. Integrated Chinese and Western Medicine College, Traditional Chinese Medicine University of ltunan , Changsha 410208, China) |
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| Abstract: | Nowadays the research of the mechanisms of cerebral ischemia/reperfusion injmy（CIRI） is mainly focused on the following aspects：excessive generation of free radicals,the exotic effect of excitmy amino acids,inflammatory response and calcium overload.Among them calcium overload and a series of harmful metabolic reactions triggered serve as the key that results in neuron injury and death after GIRI.Here is to summarize the calcium channels existing on the neuron and their changes after CIRI,revealing the neuron calcium overload mechanisms during CIRI,in order to find new targets for treating ischemia disease of the central nervous system. |
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| Keywords: | Cerebral ischemia/reperfusion injury Calcium channel Neuron |
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