硝普钠与多巴胺微量泵入治疗肾功能不全性顽固性心力衰竭的临床观察

目的观察采用微量泵泵入硝普钠与多巴胺治疗肾功能不全性顽固性心力衰竭的临床效果。方法选择2010年3月至2013年12月在张家口市第六医院住院治疗的肾功能不全的顽固性心力衰竭患者107例作为研究对象。按入院顺序的奇偶数分为传统组(54例)与微量泵组(53例),传统组在常规治疗的基础上按传统方法输注硝普钠与多巴胺;微量泵组采用微量泵持续泵入多巴胺与硝普钠。观察两组患者的疗效以及不良反应的发生率。结果微量泵组患者治疗后的临床效果与传统组比较,差异无统计学意义(Z=0.89,P>0.05);传统组有19例患者发生药物不良反应,微量泵组有6例发生药物不良反应,两组不良反应发生率比较差异有统计学意义(χ2=8.51,P<0.01)。结论采用微量泵持续泵入硝普钠与多巴胺治疗肾功能不全顽固性心力衰竭疗效可靠,安全性高,值得临床推广应用。

Clinical Observation of Micro Pump Injection of Sodium Nitroprusside Combined Dopamine Treatment of Renal Insuffidency Refractory Heart Failure

Objective To observe the clinical effect of micro pump injection of sodium nitroprusside combined dopamine for treatment of renal insufficiency refractory heart failure. Methods Total of 107 patients with renal insufficiency and refractory heart failure in Zhangjiakou Sixth Hospital from Mar. 2010 to Dec. 2013 were selected as research objects. According to admission order, the patients were divided into traditional group（54 cases） and micro pump group （53 cases）, sodium nitroprusside and dopamine were transfused by traditional infusion methods on the basis of conventional treatment in traditional control group, and by micro pump in micro pump group. The curative effect and the incidence of adverse reactions in two groups were observed. Results The clinical effect of micro pump group and traditional control group had no statistically significant difference （ Z = 0. 89, P 〉 0.05 ）. Total of 19 cases had adverse drug reactions in tradi- tional group ,6 eases in micro pump group, the difference was statistically significant （ χ2 = 8.51, P 〈 0.01 ）. Conclusion The clinical effect of micro pump injection of sodium nitroprusside combined dopamine for treat- ment of renal insufficiency refractory heart failure is reliable, safe, and it is worthy of application in clinical.