支气管肺发育不良发病机制及治疗进展研究

支气管肺发育不良(BPD)是一种慢性肺部疾病,常见于有长期机械通气及氧疗史的超低出生体质量早产儿。近年来该病的发病率逐年提高,病死率高,存活者预后常遗留高反应性呼吸道疾病、反复下呼吸道感染、喂养困难、生长发育迟缓等并发症。BPD是新生儿重症监护病房最为棘手的问题之一,严重影响早产儿存活率及生活质量,给患儿家庭带来巨大精神及经济压力,不利于我国人口质量提高。该文就BPD的病因、发病机制、预防、治疗及预后予以综述。

Study Advances in Pathogenesis and Treatment of Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia （BPD） is a chronic lung disease, which usually occurs in the extremely low birth weight premature infants with a long history of mechanical ventilation and oxygen therapy. The incidence of the disease has gradually increased in recent years. The mortality of the disease is high, and the survival often leave over complications such as high response airway diseases, recurrent lower respiratory tract infections, feeding difficulties and developmental retardation. BPD is therefore one of the most intractable problems in neonatal intensive care unit. BPD seriously affected survival rate and life quality in premature infants,which brings the family great spiritual and economic burden. Here is to make a review of the cause, pathogenesis, prevention, treatment and prognosis of BPD.