| 维生素D受体多态性的研究进展 |
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| 引用本文： | 许笑雷,赵琳.维生素D受体多态性的研究进展[J].医学综述,2014(16):2958-2960. |
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| 作者姓名： | 许笑雷 赵琳 |
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| 作者单位： | 昆明医科大学第二附属医院儿科,昆明650500 |
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| 摘 要： | 维生素D是维持人体生命所必需的营养素,只有在体内转变成1,25-(OH)2D3后,才成为有生理活性的有效物质,经过血液循环运送到各个靶器官发挥作用。维生素D受体(VDR)是介导1,25-(OH)2D3发挥生物学效应的核内生物大分子物质,VDR是由VDR基因编码,VDR基因是研究骨代谢性疾病遗传基础的候选基因之一。该文就VDR基因与钙吸收、骨量、VDR基因的协同作用以及与其基因、环境因素的交互作用对骨量影响的研究进展进行综述。
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| 关 键 词： | 维生素D受体 基因多态性 骨密度 |
Study on the Polymorphisms of Vitamin D Receptor |
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| XU Xiao-lei,ZHAO Lin.Study on the Polymorphisms of Vitamin D Receptor[J].Medical Recapitulate,2014(16):2958-2960. |
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| Authors: | XU Xiao-lei ZHAO Lin |
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| Institution: | . ( Department of Pediatrics ,the Second Affiliated Hospital of Kunming Medical University,Kunming 650500, China) |
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| Abstract: | Viatmin D is an essential nutrient for human life, only after converting into 1,25-dihydrexyvi- tamin D3 in the body does it become physiologically active material be transported into different target organs to function. The biological effect of 1,25-（OH） 2D3 is mediated by the vitamin D receptor（VDR） which is an intranuclear biomacromolecule. VDR encoded by VDR gene is one of candidate genes for exploring the hereditary basis of the bone metabolic disease. Here is to make a review of the relationship of VDR gene with calcium absorption, and bone mass, and the influence of the interaction of VDR gene＇s genetic, environmental factors on the bone mass. |
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| Keywords: | Vitamin D receptor Gene polymorphism Borle mineral density |
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