C反应蛋白、N末端脑钠肽前体、尿酸与急性心肌梗死患者全球急性冠脉事件注册危险评分相关研究

目的探讨C反应蛋白(CRP)、N末端脑钠肽前体(NT-proBNP)、尿酸在急性心肌梗死(AMI)患者中全球急性冠脉事件注册危险(GRACE)评分相关研究及临床意义。方法选择90例经临床诊断为AMI的患者,按GRACE评分结果分为低危组(25例),中危组(32例)和高危组(33例),入院时测其CRP、NT-proBNP、尿酸,分析患者CRP、NT-proBNP、尿酸与心肌梗死患者危险程度的临床意义及相关性。结果 CRP、NT-proBNP、尿酸水平随着心肌梗死患者危险程度的增加而升高(P<0.05),多元线性回归分析提示CRP、NT-proBNP、尿酸与心梗患者危险程度独立相关(P<0.05)。结论CRP、NT-proBNP、尿酸水平和GRACE评分均能有效地预测AMI死亡风险。

The Correlational Study of CRP,UA, NT-proBNP and the GRACE Score of Patients with Acute Myocardial Infarction

Objective To study the Clinical significance of C-reactive protein（CRP）,blood serun uric acid（UA）,N-terminal pro-brain natriuretic peptide（NT-proBNP） and the Global registry of acute coronary events risk model （GRACE） Score of patients with acute myocardial infarction.Methods Ninety cases of patients with cardiac acute myocardial infarction were randomly divided into three group according to the GRACE Score：the low risk group（25 cases）,the middle risk group（32 cases） and the high risk group（33cases）.The level of C-reactive protein（CRP）,blood serum uric acid（UA） and N-terminal pro-brain natriuretic peptide（NT-proBNP） were tested when those patients admitted in the hospital.Analyzed the clinical significance and correlation of CRP,NT-proBNP,UA with the risk level ofthose patients with myocardial infarction.Results The level of CRP,NT-proBNP,UA increased correspondingly with the risk level of the patients with myocardial infarction（P 〈 0.05）.Multiple linear regression analysis showed that CRP,NT-proBNP,UA and risk level of the patients with myocardial infarction were correlated independently.Conclusion The index of CRP,NT-proBNP,UA and GRACE all apply effectively in the prognosis of patients with AMI.