高血压患者动态血压变异性与心室重构的关系研究

目的探讨高血压患者动态血压变异性与心室重构的关系。方法选取2011年4月至2013年4月武汉市第八医院治疗的高血压患者140例为高血压组,体检正常者140例为血压正常组。分别于7:00²2:00(日间)每15分钟自动测量一次血压,22:0022:00(日间)每15分钟自动测量一次血压,22:00⁷:00(夜间)每30分钟自动测量一次血压,比较两组24 h平均收缩压、24 h平均舒张压、24 h血压变异性、舒张期左心室后壁厚度(LVPWT)、舒张期室间隔厚度(IVST)、左心室舒张末期内径(LVIDd)、左心室质量指数(LVMI)。结果高血压组的24 h平均收缩压、24 h平均舒张压、收缩压标准差、舒张压标准差、LVPWT、IVST、LVIDd和LVMI均显著高于血压正常组(131.8±14.8)mm Hg vs(124.2±15.8)mm Hg、(80.6±9.2)mm Hg vs(75.3±9.6)mm Hg、(12.3±3.1)mm Hg vs(10.2±3.2)mm Hg、(8.9±2.5)mm Hg vs(7.8±2.5)mm Hg、(10.7±3.2)mm vs(9.6±2.9)mm、(11.9±1.9)mm vs(9.2±1.9)mm、(53.1±7.4)mm vs(49.5±8.2)mm、(45.2±5.2)g/m2vs(42.1±6.4)g/m2(P<0.05)]。结论相比于正常人,高血压患者的动态血压变异性更为显著,其心室重构更加明显。

The Study on the Relationship between Hypertension Ambulatory Blood Pressure Variability and Ventricular Remodeling

Objective To investigate the relationship between hypertension ambulatoU blood pressure variability and ventricular remodeling.Methods Chosen between Apr.2011 and Apr.2013 from Wuhan City Eighth Hospital 140 cases of hypertensionwere included as hypertension group and 140 people for health check-up during the same period were included as the normal blood pressure group.During 7：00-22：00 （dayy） every 15 minutes automatic measurement of the blood pressure was done,during 22：00-7：00 （night）every 30 minutes automatic measurement of the blood pressure was done,and the 24 h average systolic pressure,diastolic pressure,24h variability of blood pressure,left ventricular diastolic posterior wall thickness （LVPWT）,interventricular septal thickness（IVST）,left ventricular end diastolic diameter（LVIDd）,and left ventricular mass index （LVMI） of the groups were compared.Results The 24h average systolic pressure,diastolic pressure,systolic pressure,diastolic pressure standard deviation,standard deviation,LVPWT,IVST,LVIDd and LVMI of the hypertension group were significantly higher than the normal blood pressure group （131.8±14.8）mm Hgvs（124.2±15.8） mm Hg,（80.6±9.2）mm Hg vs（75.3 ±9.6） mm Hg,（12.3±3.1） mmHgvs（10.2±3.2） mmHg,（8.9±2.5） mm Hgvs（7.8±2.5） mm Hg,（10.7 ± 3.2）mmvs（9.6±2.9）mm,（11.9±1.9）mm vs（9.2±1.9） mm,（53.1±7.4）mm vs（49.5±8.2）mm,（45.2 ± 5.2） g/m2 vs （42.1 ± 6.4） g/m2,P 〈 0.05].Conclusion Compared to the normal people,ambulatory blood pressure variability of hypertensive people is more significant,and the ventricular remodeling is more significant as well.