白细胞介素33水平与非小细胞肺癌相关性研究 |
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引用本文: | 牛淑丽,;王建芳,;王智霞,;王伟宝,;常占英,;高树雨.白细胞介素33水平与非小细胞肺癌相关性研究[J].医学综述,2014(16):3014-3015. |
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作者姓名: | 牛淑丽 ;王建芳 ;王智霞 ;王伟宝 ;常占英 ;高树雨 |
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作者单位: | [1]张家口市第四医院检验科,河北张家口075000; [2]康保县人民医院检验科,河北康保075000 |
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摘 要: | 目的检测非小细胞肺癌(NSCLC)患者血清中白细胞介素33(IL-33)的变化,探讨两者是否具有相关性。方法选取2012年1月至2013年3月于张家口市第四医院进行诊治的49例NSCLC患者作为NSCLC组,同时选取50例健康献血者作为健康对照组,应用酶联免疫吸附试验法检测血清中IL-33水平,并进行统计学分析。结果 NSCLC患者血清中的IL-33 364(178537)ng/L,显著高于健康对照组的156(52537)ng/L,显著高于健康对照组的156(52193)ng/L(P<0.05),且肿瘤恶性程度越高,IL-33水平升高越明显,两者呈正相关(r=0.31,P<0.05);不同病理类型患者间IL-33水平的差异无统计学意义(P>0.05)。结论 NSCLC患者血清中IL-33水平高于健康对照者,且与肿瘤分期呈正相关,可作为评估疾病恶性分期的潜在指标,为临床治疗提供一定的理论依据。
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关 键 词: | 非小细胞型肺癌 白细胞介素33 酶联免疫吸附试验 |
The Research on Correlation of Interleukin-33 and Non.small Cell Lung Cancer |
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Institution: | NIU Shu-li , WANG Jian-fang, WANG Zhi-xia , WANG Wei-bao , CHANG Zhan-ying , GAO Shu-yu ( 1. Department of Clinical Laboratory, Zhangjiakou Fourth Hospital, Zhangjiakou 075000, China ; 2. Department of Clinical Laboratory, Kangbao People's Hospital ,Kangbao 075000, China) |
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Abstract: | Objective To test the serum interleukin-33 (IL-33) level in non-small cell lung cancer patients( NSCLC), and to explore the correlation of IL-33 and NSCLC. Methods Altogether 49 NSCLC patients and 50 healthy volunteers in Zhangjiakou Fourth Hospital from Jan. 2012 to Mar. 2013 were collected as research objects, serum IL-33 level were detected by ELISA, and statistically analyzed. Results IL-33 levels were higher in NSCLC patients364(178-537)pg/ml] than healthy volunteers 156(52-193)pg/ml, P 〈0.05 ], and the higher of the malignant degree, the higher the IL-33 levels, with a positive correlation (r =0.31 ,P 〈 0.05 ); IL-33 levels between patients with different pathological types had no statistical difference ( P 〉 0.05 ). Conclusion IL-33 levels are higher in NSCLC patients than the healthy volunteers, and were positively associated with tumor stage. Serum IL-33 can be used to evaluate the rlaalignancy degree of NSCLC, and provide clinical basis for disease treatment. |
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Keywords: | Non-small cell lung cancer Iinterleukin-33 Enzyme-linked immunosorbent assay |
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