| NO代谢变化对缺血性脑组织内皮素产生的影响 |
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| 引用本文： | 赵卫国,田恒力.NO代谢变化对缺血性脑组织内皮素产生的影响[J].中华神经外科杂志,1996,12(3):171-173. |
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| 作者姓名： | 赵卫国 田恒力 |
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| 作者单位： | 上海第二医科大附属瑞金医院神经外科 |
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| 摘 要： | 在兔大脑中动脉阻断（ＭＣＡｏ）型局灶脑缺血前后分别应用外源性一氧化氮合成酶（ＮＯＳ）抑制剂Ｌ－ＮＮＡ和ＮＯ合成底物Ｌ－ａｒｇｉｎｉｎｅ，观察缺血４小时后脑组织内皮素（ＥＴ）含量的变化。结果发现Ｌ－ＮＮＡ组较缺血对照组脑组织ＥＴ含量明显增多（１２６２．９±３８７．６ｖｓ７８９．３±１８８．４ｐｇ／ｍｇ·ｐｒｏ，Ｐ值＜０．０１），脑水肿显著；而Ｌ－ａｒｇｉｎｉｎｅ用药组脑组织ＥＴ含量较缺血对照组明显减少（Ｐ值＜０．０５），且脑水肿减轻。本研究提示ＮＯ能抑制缺血脑组织ＥＴ的产生。ＮＯ对脑缺血影响可能与此途径有关。
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| 关 键 词： | 脑缺血，脑水肿，一氧化氮，内皮素 |
Influence of nitric oxide metabolism on cerebral endothelin production in rabbit MCA occlusion model of brain ischemia |
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| Zhao Weiguo,Tian Henli, Zhang Tianxi,et al..Influence of nitric oxide metabolism on cerebral endothelin production in rabbit MCA occlusion model of brain ischemia[J].Chinese Journal of Neurosurgery,1996,12(3):171-173. |
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| Authors: | Zhao Weiguo Tian Henli Zhang Tianxi |
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| Institution: | Zhao Weiguo,Tian Henli, Zhang Tianxi, et al. |
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| Abstract: | We observed the level of cerebral endothelin and development of ischemic brain edema four hours after occlusion of MCA in rabbit after using exogenous NOS inhibitor L-NN A and L-Arginine(a substrate for NO biosynthesis) respectively. The results show that the level of ET in ischemic brain increased significantly in animal group receiving L-NNA with more prominent brain edema and dereased in group receiving L-Arginine with less brain edema, These findings suggest that mitigation of brain edema in four hours ischemia may involve the mechanism of NO, which inhibit cerebral ET production. |
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| Keywords: | Cerebral ischemia Brain edema NO Endothelin |
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