环氧合酶在宫颈癌组织中的表达及其与临床病理特征的关系

目的:探讨环氧合酶-2(COX-2)在宫颈癌组织中的表达情况及其与临床病理特征的关系.方法:对46例手术切除的宫颈癌组织及31例正常宫颈组织进行免疫组化染色,检测CoX-2的表达.结果:宫颈癌组织中COX-2的表达阳性率为67.39%(31/46),明显高于正常宫颈组织中COX-2的表达(阳性率为6.45%,P＜0.01).COX-2的高表达与肿瘤的淋巴结转移(P=0.009)、分化程度(P＜0.005)、浸润(P=0.001)、临床分期(P＜0.01)有关.结论:COX-2基因蛋白在宫颈癌组织中有高水平的表达,并在宫颈癌的发生、发展及淋巴结转移中起作用.

Expression of COX-2 in cervical cancer and its relationship to clinicopathologic characteristic

Objective: To study the expression of COX-2 in cervical cancer and its relationship to cli nicopathologic characteristic. Methods:Forty-six cases of cervical cancer were studied with immunohistochemical staining to detect the expression of COX-2. Results: The positive rate of COX-2 expression in cervical cancer was 67.39% and obviou sly higher than that of the normal cervical tissues. Overex pression of COX-2 in cervical cancer was related with lymph node metastasis( P=0.009) , differentiation degree(P<0.005),infilt ration(P=0.001) and pathologic grading(P<0 .01). Conclusion: The overexpression of COX-2 in cervical cancer may play an important role in th e carcinogenesis and development of cancer.COX-2 expression is associated with lymphatic metastasis and other clinicopathological features in patients with ce rvical cancer.