Orotic acid, a promoter of liver carcinogenesis induces DNA damage in rat liver |
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| Authors: | Rao Prema M; Rajalakshmi S; Alam Ayesha; Sarma DSR; Pala M; Parodi S |
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| Institution: | Department of Pathology, Medical Sciences Building, University Toronto Toronto, Ontario M5S 1A8, Canada
1Instituto Scientifico per to Studio e la Eura dei Tumori and Department of Oncology, University of Genoa Genoa, Italy |
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| Abstract: | Orotic acid, a precursor of pyrimidine nucleotide biosynthesisand a promoter for liver carcinogenesis, when fed at 1% levelin a diet for 5 weeks resulted in liver DNA damage. The damagecan be monitored as alkali-labile lesions using alkaline sucrosegradients as well as alkaline elution technique. Furthermore,the induced DNA damage persists for up to three weeks afterwithdrawal of the orotic acid diet. The fad that several skin-tumourpromoters also induce DNA damage raises the question whetherDNA damage is a component in tumour promotion. |
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