| 一阶导数光谱法测定丙吡胺尿药浓度及其缓释片的相对生物利用度 |
| |
| 引用本文： | 王培玉,马迎,杨秀明. 一阶导数光谱法测定丙吡胺尿药浓度及其缓释片的相对生物利用度[J]. 北京大学学报(医学版), 1990, 0(1) |
| |
| 作者姓名： | 王培玉 马迎 杨秀明 |
| |
| 作者单位： | 北京医科大学药学院(王培玉，马迎)，北京医科大学药学院(杨秀明) |
| |
| 摘 要： | 本文报道了用导数光谱法测定磷酸丙吡胺的尿药浓度,本方法能消除尿中杂质干扰,测定结果准确。6名受试者交叉口服磷酸丙吡胺缓释片和普通片,测得尿药浓度计算消除速度常数K,排泄速率(Δx/Δt)_(max) 所需时间,证明缓稀片药物排泄慢,药效维持时间长,且缓释片的相对生物利用度与普通片基本相同。
|
| 关 键 词： | 丙吡胺缓释片 一阶导数光谱法 生物利用度 |
THE APPLICATION OF FIRST DERIVATIVE SPECTRO METRY IN DETERMINATION OF URINE DISOPYRA MIDE CONCENTRATION FOR EVALUATION THE RELATIVE BIOAVAILABILITY OF DISOPYRAMIDE SUSTAINED RELEASE TABLETS |
| |
| Wang Peiyu School of Pharmacy. THE APPLICATION OF FIRST DERIVATIVE SPECTRO METRY IN DETERMINATION OF URINE DISOPYRA MIDE CONCENTRATION FOR EVALUATION THE RELATIVE BIOAVAILABILITY OF DISOPYRAMIDE SUSTAINED RELEASE TABLETS[J]. Journal of Peking University. Health sciences, 1990, 0(1) |
| |
| Authors: | Wang Peiyu School of Pharmacy |
| |
| Affiliation: | Wang Peiyu School of Pharmacy |
| |
| Abstract: | First derivative spectrometry was selected for determining levels of disopyramide in urine. Six subjects took part in investigations both on disopyramide sustained release tablets and onplain tablets in a cross over way. There is no significant difference in the relative bioavailabilitybetween disopyramide sustaincd release tablets and plain tablets. |
| |
| Keywords: | Disopyramide sustained release tablets First derivative spectrometry Bioavailability |
| 本文献已被 CNKI 等数据库收录！ |
