鼻咽癌组织中的癌胚抗原

应用未标记免疫酶技术(PAP法)显示94例鼻咽癌和52例慢性鼻咽炎组织切片中的癌胚抗原(CEA)。鼻咽癌的CEA阳性率为28.7％,分化差的腺癌CEA阳性率(53.8％)显著高于分化差的鳞癌(17.6％),未分化癌失去产生CEA的能力。CEA含量与癌瘤分化程度有关。分化好的鳞癌角化区域和慢性鼻咽炎中正常鳞状上皮CEA阳性反应可能是抗CEA血清与角质或前角质物质交叉反应的结果。鼻咽假复层纤毛柱状上皮CEA阳性率为35.7％(15/42),似与鼻咽的粘膜炎症轻重有关,本组轻度炎症者仅10例CEA均为阴性。本文还对鼻咽癌组织中CEA出现的生物学意义作了初步分析。

Carcinoembryonic Antigen (CEA) in Nasopharyngeal carcinoma

94 cases of nasopharyngeal carcinoma (NPC) and 52 nasopharyngitis have been studied immunohistochemically for the presence of carcinoembryonic antigen (CEA) within tumor cells and nasopharyngeal epiethelial cells. 28. 7% of the NpC was positive for CEA. The relationship between the presence of CEA and the histological type and diffirentiation of the tumors was investi- gated. The positive incidence of CEA. in poorly-differentiated adenocarcinoma of nasopharynx was much higher (53. 8%) than that of poorly-differentiated squamous type (17. 6%) and no CEA was found in undifferentiated ones, The positivs reaction seen in well-differentiated squmous-cell carcinoma, especia- lly in the cornified components and that in the squamous epithelium of chr- onic nasopharyngitis was explained as a cross-reacting phenomenon from Ker- atin or Keratis precursor. Lymphocytic infiltration in the tumor did not show any influence on the presence of CEA. pseadostratified columnar epithelium was also positive for CEA in 15/42 (35. 7%). Its close association with inflammation in the nasopharynx was obvious as no CEA was demonstrated in a series of mild nasopharyngitis 0/10 (0%) but increased while inflammations became prominent 15/32 (46. 9%). Thus, CEA, as a tumor marker, was considered to be non-specific but its biological significance in prognosis of NPC has been emphasized.