原发性痛经穴位敏化的规律及理论探讨

目的：通过文献研究及数据挖掘总结原发性痛经穴位敏化规律并进行理论探讨，为原发性痛经的临床诊疗提供科学指导。方法：计算机检索国家知识基础设施数据库（CNKI）、中国学术期刊数据库（CSPD）、中文科技期刊数据库（CCD）、中国生物医学文献数据库（CBM)、PubMed、Cochrane Library等数据库，收集整理原发性痛经穴位敏化相关文献，采用文献计量学及数据挖掘方法，总结穴位敏化现象，探索穴位敏化规律，并对原发性痛经穴位敏化规律进行相关理论探讨。结果：共纳入原发性痛经穴位敏化相关文献55篇。原发性痛经穴位敏化现象有热敏、痛敏、电敏、形敏、化学敏5种，热敏出现频次最高；共涉及敏化穴位22个，总频次为161次，常见敏化穴位有三阴交（39次）、关元（33次）、次髎（15次）、中极（14次）、子宫（13次）；其中关元和三阴交敏化相关性支持度（64%）最高，置信度（81.25%）；共涉及9种特定穴，其中频次最高的特定穴为交会穴（86次）；敏化穴位归属经络以足太阴脾经（57次）和任脉（52次）为主。结论：原发性痛经穴位敏化现象以热敏为主；敏化穴位以三阴交穴和关元穴较为多见。中医理论及现代研究皆证明三阴交穴、关元穴及足太阴脾经、任脉对原发性痛经诊疗的高效性及特殊性。

Rule and Theory of Acupoint Sensitization of Primary Dyspenorrhea

To summarize and theoretically discuss the rule of acupoint sensitization of primary dyspenorrhea based on literature research and data mining,and to provide scientific guidance for the clinical diagnosis and treatment of primary dyspenorrhea.Methods:CNKI,CSPD,CCD,CBM,PubMed and Cochrane Library were retrieved to collect the literature related to acupoint sensitization of primary dysenenorrhea.The classification of acupoint sensitization was summarized and the rules of acupoint sensitization were explored by bibliometrics and data mining.In addition,theoretical discussion on the rules of acupoint sensitization of primary dyspenorrhea was conducted.Results:A total of 55 literature related to acupoint sensitization of primary dyspenorrhea was included,and five types of acupoint sensitization were involved:heat sensitization,pain sensitization,electro sensitization,shape sensitivity and chemical sensitivity,with heat sensitivity having the highest frequency.There were 22 sensitized acupoints involved,and the total frequency was 161 times.The common sensitized acupoints were Sanyinjiao(SP 6,39 times),Guanyuan(CV 4,33 times),Ciliao(BL 32,15 times),Zhongji(CV 3,14 times) and Zigong(EX-CA 1,13 times),among which Guanyuan and Sanyinjiao had the highest support(64%) and confidence interval(81.25%).Additionally,nine specific points were involved,and the confluence points had the highest frequency(86 times).The sensitized acupoints mainly acted on foot greater yin spleen channel(SP,57 times) and conception vessel(CV,52 times).Conclusion:The main acupoint sensitization of primary dyspenorrhea was heat sensitization,and the sensitization occurred more commonly in Sanyinjiao and Guanyuan.Both traditional Chinese medicine theory and modern research confirmed the high efficiency and specificity of primary dysmenorrhea treatment via Sanyinjiao,Guanyuan,foot greater yin spleen channel and conception vessel.