盐酸氨溴索联合利奈唑胺治疗重症肺炎患者的临床疗效及对血气指标的影响分析

目的 探讨盐酸氨溴索联合利奈唑胺治疗重症肺炎患者的临床疗效及对血气指标的影响.方法 选取2019年2月～2020年1月于我院住院治疗的116例重症肺炎患者作为研究对象,采用随机数字表法分为观察组和对照组,每组各58例.其中对照组采用利奈唑胺治疗,观察组在对照组治疗基础上加用盐酸氨溴索液治疗,均治疗7d.治疗后比较两组患...

Effects of Ambroxol Hydrochloride Combined with Linezolid on Clinical Curative Effect and Blood Gas Indexes in Patients with Severe Pneumonia

Objective This study aimed to explore the effects of ambroxol hydrochloride combined with linezolid on clinical curative effect and blood gas indexes in patients with severe pneumonia. Methods A total of 116 patients with severe pneumonia admitted to our hospital from February 2019 to January 2020 were enrolled as the research objects. They were randomly divided into observation group(n=58) and control group(n=58) with a random number table by using block randomization. The control group was treated with linezolid, while observation group was treated with ambroxol hydrochloride and linezolid. All patients were treated for 7 d. The total response rate after treatment were evaluated, inflammatory cytokines [TNF-α,, HMGB1, IL-1β] and blood gas indexes [PaO₂, PaCO₂, SaO₂] was recorded before and after treatment, and incidence of adverse reactions during treatment were compared between the two groups. Results After treatment, the total response rate of treatment in observation group was significantly higher than that in control group(P<0.05). The disappearance time of fever, cough, expectoration and lung rales, and negative conversion time of sputum bacteria in observation group were shorter than those in control group(P<0.05). The levels of serum TNF-α,, HMGB1 and IL-1β, and PaCO₂ in observation group were lower than those in control group(P<0.05), while PaO₂ and SaO₂ were higher than those in control group(P<0.05).Conclusion The application of ambroxol hydrochloride combined with linezolid in the treatment of patients with severe pneumonia can significantly improve blood gas indexes, reduce levels of inflammatory cytokines, with good clinical curative effects.