Differences in morphine-induced antinociception and locomotor activity in mature adult and aged mice |
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| Authors: | B Hoskins C K Burton I K Ho |
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| Affiliation: | 1. Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA;2. Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA;3. Insitute for Drug and Alcohol Studies, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA;1. Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa;2. Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Medical School Cape Town, South Africa;3. Department of Epidemiology, Mailman School of Public Health, Columbia University, NY, USA;4. National Health Laboratory Service, South Africa;1. Keck School of Medicine, University of Southern California, 1200 North State Street, Suite 3300, Los Angeles, CA 90033, USA;2. Department of Neurological Surgery, Keck School of Medicine, University of Southern California, 1200 North State Street, Suite 3300, Los Angeles, CA 90033, USA;3. Department of Neurological Surgery, Tulane School of Medicine, Tulane University, 131 South Robertson Street, Suite 1300, New Orleans, LA 70112, USA;4. Neurorestoration Center, Keck School of Medicine, University of Southern California, 1200 North State Street, Suite 3300, Los Angeles, CA 90033, USA;1. Department of Clinical Laboratory Medicine, Shanghai, China;2. Department of Pathogen Diagnosis and Biosafety, Shanghai Public Health Clinical Centre, Shanghai, China |
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| Abstract: | Mature adult (3-6 months old) and aged (24-27 months old) male ICR mice were injected with 10 to 100 mg/kg morphine, SC. The ED50 values for locomotor behavior representing 5 times control activity were 7.5 mg/kg for aged mice and 17.8 mg/kg for the mature adults. There were striking age- and dose-dependent differences in both intensities and durations of morphine-induced locomotor activity. The ED50 values for antinociception 1 hour after morphine administration were 70 mg/kg for the aged mice and 13 mg/kg for the mature adults. One hour after injecting 30 and 100 mg/kg morphine tagged with 3H-morphine, 0.13 and 0.14 percent of the doses appeared in brains of aged and mature adult mice, respectively. Distribution of morphine among brain regions was the same for both age groups. The results suggest that the differences in response to morphine by the two age groups were due to age-related differences in affinities, numbers and/or functioning of opioid receptors and not to pharmacokinetic differences. |
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